Stabilization of Pluronic Gels in the Presence of Different Polysaccharides

被引：23

作者：

Kjoniksen, Anna-Lena ^{[1
,2
]}

Calejo, Maria Teresa ^{[1
,3
]}

Zhu, Kaizheng ^{[4
]}

Nystrom, Bo ^{[4
]}

Sande, Sverre Arne ^{[1
]}

机构：

[1] Univ Oslo, Sch Pharm, Dept Pharm, N-0316 Oslo, Norway

[2] Ostfold Univ Coll, Fac Engn, N-1757 Halden, Norway

[3] Tampere Univ Technol, Dept Elect & Commun Engn, FI-33101 Tampere, Finland

[4] Univ Oslo, Dept Chem, N-0315 Oslo, Norway

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2014年 / 131卷 / 13期

关键词：

gels; polysaccharides; stimuli-sensitive polymers; grafting; self-assembly; CONTROLLED DRUG-DELIVERY; AQUEOUS-SOLUTIONS; CONTROLLED-RELEASE; POLOXAMER; 407; IN-SITU; HYDROGELS; COPOLYMERS; POLYMER; SYSTEM; TRANSITION;

D O I：

10.1002/app.40465

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Several different polysaccharides have been added to pluronic F127 (poloxamer 407) gels to test their ability to stabilize the gels against dissolution in aqueous media over time. The studied polysaccharides include -carrageenan, chitosan, hyaluronic acid, pectin, alginate, hydroxyethylcellulose, and ethyl(hydroxyethyl)cellulose. Although all the considered polysaccharides slowed down the dissolution time of the pluronic gels, unmodified polysaccharides only had a modest stabilization effect. However, hydrophobic modification of polysaccharides with a sufficiently long hydrocarbon chain (C-16) was found to partly prevent the gels from dissolving for more than 6 months. Shorter hydrocarbon chains did not have the same effect, even at high degrees of hydrophobicity. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40465.

引用

页数：8

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