Three aeruginosins and a microviridin from a bloom assembly of Microcystis spp. collected from a fishpond near Kibbutz Lehavot HaBashan, Israel

被引：22
|
作者：
Vegman, Margarita
Carmeli, Shmuel [1 ]
机构：
[1] Tel Aviv Univ, Raymond & Beverly Sackler Sch Chem, IL-69978 Ramat Aviv, Israel
来源：
TETRAHEDRON | 2014年 / 70卷 / 38期
基金：
以色列科学基金会;
关键词：
Microcystis; Protease inhibitors; Aeruginosins; Microviridin; ANABAENA-FLOS-AQUAE; PROTEASE INHIBITORS; ELASTASE INHIBITORS; SERINE PROTEASES; CYCLIC-PEPTIDES; FRESH-WATER; CYANOBACTERIA; BIOSYNTHESIS; THROMBIN; VIRIDIS;
D O I：
10.1016/j.tet.2014.07.057
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Four new metabolites, aeruginosins LH650A (1), LH650B (2), and LH606 (3), and microviridin LH1667 (4) were isolated along with the two known aeruginosins 98-A and DA495B, and previously isolated metabolites, from a bloom material of Microcystis spp., collected from a fishpond near Kibbutz Lehavot HaBashan, Israel. Their structures were elucidated by a combination of various spectroscopic techniques; primarily NMR and MS, while the absolute configuration of the chiral centers was determined by Marfey's method and chiral-phase HPLC. The structures and biological activities of the four new metabolites are described. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6817 / 6824
页数：8
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