Celebrating Soft Matter's 10th Anniversary: Cell division: a source of active stress in cellular monolayers

被引：76

作者：

Doostmohammadi, Amin ^{[1
]}

Thampi, Sumesh P. ^{[1
]}

Saw, Thuan B. ^{[2
]}

Lim, Chwee T. ^{[2
,3
]}

Ladoux, Benoit ^{[2
,4
]}

Yeomans, Julia M. ^{[1
]}

机构：

[1] Rudolf Peierls Ctr Theoret Phys, Oxford OX1 3NP, England

[2] Natl Univ Singapore, Mechanobiol Inst, Singapore 117411, Singapore

[3] Natl Univ Singapore, Dept Biomed Engn, Singapore 117575, Singapore

[4] Univ Paris Diderot, CNRS UMR 7592, Inst Jacques Monod, F-75013 Paris, France

来源：

SOFT MATTER | 2015年 / 11卷 / 37期

关键词：

MIGRATION; FLOW; TRANSITION; FORCES; MODEL;

D O I：

10.1039/c5sm01382h

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We introduce the notion of cell division-induced activity and show that the cell division generates extensile forces and drives dynamical patterns in cell assemblies. Extending the hydrodynamic models of lyotropic active nematics we describe turbulent-like velocity fields that are generated by the cell division in a confluent monolayer of cells. We show that the experimentally measured flow field of dividing Madin-Darby Canine Kidney (MDCK) cells is reproduced by our modeling approach. Division-induced activity acts together with intrinsic activity of the cells in extensile and contractile cell assemblies to change the flow and director patterns and the density of topological defects. Finally we model the evolution of the boundary of a cellular colony and compare the fingering instabilities induced by cell division to experimental observations on the expansion of MDCK cell cultures.

引用

页码：7328 / 7336

页数：9

共 58 条

[1] Alignment of cellular motility forces with tissue flow as a mechanism for efficient wound healing [J].

Basan, Markus ;

Elgeti, Jens ;

Hannezo, Edouard ;

Rappel, Wouter-Jan ;

Levine, Herbert .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (07) :2452-2459

[2] Undulation Instability of Epithelial Tissues [J].

Basan, Markus ;

Joanny, Jean-Francois ;

Prost, Jacques ;

Risler, Thomas .

PHYSICAL REVIEW LETTERS, 2011, 106 (15)

[3] Quantification of growth asymmetries in developing epithelia [J].

Bittig, T. ;

Wartlick, O. ;

Gonzalez-Gaitan, M. ;

Juelicher, F. .

EUROPEAN PHYSICAL JOURNAL E, 2009, 30 (01) :93-99

[4] Dynamics of anisotropic tissue growth [J].

Bittig, Thomas ;

Wartlick, Ortrud ;

Kicheva, Anna ;

Gonzalez-Gaitan, Marcos ;

Juelicher, Frank .

NEW JOURNAL OF PHYSICS, 2008, 10

[5] Biphasic, Lyotropic, Active Nematics [J].

Blow, Matthew L. ;

Thampi, Sumesh P. ;

Yeomans, Julia M. .

PHYSICAL REVIEW LETTERS, 2014, 113 (25)

[6] A tense situation: forcing tumour progression [J].

Butcher, Darci T. ;

Alliston, Tamara ;

Weaver, Valerie M. .

NATURE REVIEWS CANCER, 2009, 9 (02) :108-122

[7] Individual-based and continuum models of growing cell populations: a comparison [J].

Byrne, Helen ;

Drasdo, Dirk .

JOURNAL OF MATHEMATICAL BIOLOGY, 2009, 58 (4-5) :657-687

[8] FREE ENERGY OF A NONUNIFORM SYSTEM .1. INTERFACIAL FREE ENERGY [J].

CAHN, JW ;

HILLIARD, JE .

JOURNAL OF CHEMICAL PHYSICS, 1958, 28 (02) :258-267

[9] Tension-oriented cell divisions limit anisotropic tissue tension in epithelial spreading during zebrafish epiboly [J].

Campinho, Pedro ;

Behrndt, Martin ;

Ranft, Jonas ;

Risler, Thomas ;

Minc, Nicolas ;

Heisenberg, Carl-Philipp .

NATURE CELL BIOLOGY, 2013, 15 (12) :1405-+

[10] Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells [J].

Cheng, Gang ;

Tse, Janet ;

Jain, Rakesh K. ;

Munn, Lance L. .

PLOS ONE, 2009, 4 (02)

← 1 2 3 4 5 6 →