Mitochondria at the synapse

被引：163
作者：
Ly, Cindy V. [1 ]
Verstreken, Patrik [1 ]
机构：
[1] Baylor Coll Med, Howard Hughes Med Inst, Dept Neurosci & Mol & Human Genet, Houston, TX 77030 USA
来源：
NEUROSCIENTIST | 2006年 / 12卷 / 04期
关键词：
neurotransmission; mitochondria; synapse; ATP; reserve pool;
D O I：
10.1177/1073858406287661
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Synapses are packed with mitochondria, complex organelles with roles in energy metabolism, cell signaling, and calcium homeostasis. However, the precise mechanisms by which mitochondria influence neurotransmission remain undefined. In this review, the authors discuss pharmacological and genetic analyses of synaptic mitochondrial function, focusing on their role in Ca2+ buffering and ATIP production. Additionally, they will summarize recent data that implicate synaptic mitochondria in the regulation of neurotransmitter release during intense neuronal activity and link these findings to the pathogenesis of neuroclegenerative diseases that feature disrupted synaptic mitochondria, including annyotrophic lateral sclerosis and hereditary spastic paraplegia.
引用
收藏
页码：291 / 299
页数：9
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