Synthesis, Characterization and in vitro Biological Activity of Mixed Transition Metal Complexes of Lornoxicam with 1,10-phenanthroline

A new series of Cr(III), Mn(II), Fe(II), Fe(III), Co(II), Ni(II) and Zn(II) ternary complexes derived from lornoxicam and 1,10-phenanthroline (Phen) have been synthesized and characterized by spectroscopic studies. The coordination possibility of the two ligands towards metal ions have been proposed in the light of elemental analysis, spectral (mass, IR, UV-vis, H-1 NMR and ESR), X-ray powder diffraction, magnetic and thermal studies. IR spectra show that LOR and Phen are coordinated to the metal ions in a neutral bidentate manner. The molar conductance measurements of the complexes in DMF correspond to electrolytic nature of the ternary complexes, thus, these complexes may be formulated as [M(LOR)(Phen)Cl-2] X-n.yH(2)O (M = Cr(III) (n = 1, y = 2) and Ni(II) (n = 0, y = 1); [M(LOR)(Phen)(H2O)(2)](BF4)(2) (M = Fe(II), Co(II), Cu(II) and Zn(II)) and [M(LOR)(2)(Phen)] X-n.yH(2)O (M = Mn(II) (n = y = 2) and Fe(III) (n = 3, y = 0)). On the basis of magnetic moment, electronic and ESR spectral studies, an octahedral geometry has been assigned for the ternary complexes. Furthermore, the kinetic and thermodynamic parameters for the different decomposition steps were calculated using the Coats-Redfern and Horowitz-Metzger methods. Also, the two ligands, in comparison to ternary metal complexes are screened for their antimicrobial and anticancer activity against breastic cancer cell line. The results showed that the metal complexes be more active than the parent LOR ligand but less active than 1,10-phenanthroline free ligand. The Co(II) and Cu(II) metal complexes completely missed anticancer activity.