Variation of Blood T Lymphocyte Subgroups in Patients with Non-small Cell Lung Cancer

被引：36
作者：
Wang, Wen-Jing [1 ]
Tao, Zhen [1 ]
Gu, Wei [2 ]
Sun, Li-Hua [2 ]
机构：
[1] Nanjing Med Univ, Nanjing Hosp 1, Dept Infect Dis, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Nanjing Hosp 1, Dept Respirat, Nanjing, Jiangsu, Peoples R China
来源：
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2013年 / 14卷 / 08期
关键词：
Non-small cell lung cancer; lymphocyte subset; flow cytometry; cellular immune; CHEMOTHERAPY;
D O I：
10.7314/APJCP.2013.14.8.4671
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objectives: To study variation in T lymphocyte subgoups and its clinical significance in non-small cell lung cancer (NSCLC). Methods: Levels of CD3+, CD4+, CD8+, CD4+/CD8+, NK and Treg cells in peripheral blood of NSCLC cases and healthy adults were determined by flow cytometry. Results: CD3+, CD4+ and CD4+/CD8+ ratio and NK cells in NSCLCs were decreased significantly in comparison with the control group (P < 0.01), and decreased with increase in the clinical stage of NSCLC, while CD8+ cells demonstrated no significant change (P > 0.05). Treg cells were significantly more frequent than in the control group (P < 0.01), and increased with the clinical stage of NSCLC. Conclusion: The cellular immune function of the NSCLC patients is lowered. It is important to detect change of T lymphocyte subgroups by flow cytometry for the diagnosis, treatment and prognostic assessment of NSCLC patients.
引用
收藏
页码：4671 / 4673
页数：3
相关论文
共 15 条
[1]   Circulating Lymphocytes as Predictors of Sensitivity to Preoperative Chemoradiotherapy in Rectal Cancer Cases [J].
Dou, Xue ;
Wang, Ren-Ben ;
Yan, Hong-Jiang ;
Jiang, Shu-Mei ;
Meng, Xiang-Jiao ;
Zhu, Kun-Li ;
Xu, Xiao-Qing ;
Mu, Dian-Bin .
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2013, 14 (06) :3881-3885
[2]   Genotoxic and Anti-Genotoxic Effects of Vanillic Acid Against Mitomycin C-Induced Genomic Damage in Human Lymphocytes In Vitro [J].
Erdem, Merve Guler ;
Cinkilic, Nilufer ;
Vatan, Ozgur ;
Yilmaz, Dilek ;
Bagdas, Deniz ;
Bilaloglu, Rahmi .
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2012, 13 (10) :4993-4998
[3]   On the effect of biochemotherapy in metastatic malignant melanoma:: An immunopathological evaluation [J].
Håkansson, A ;
Håkansson, L ;
Gustafsson, B ;
Krysander, L ;
Rettrup, B ;
Ruiter, D ;
Bernsen, MR .
MELANOMA RESEARCH, 2003, 13 (04) :401-407
[4]   Semiconductor quantum dot/albumin complex is a long-life and highly photostable endosome marker [J].
Hanaki, K ;
Momo, A ;
Oku, T ;
Komoto, A ;
Maenosono, S ;
Yamaguchi, Y ;
Yamamoto, K .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 302 (03) :496-501
[5]  
JASON D, 2003, NAT IMMUNOL, V4, P330
[6]   Relationship between Colonic Polyp Type and the Neutrophil/Lymphocyte Ratio as a Biomarker [J].
Karaman, Hatice ;
Karaman, Ahmet ;
Erden, Abdulsamet ;
Poyrazoglu, Orhan Kursat ;
Karakukcu, Cigdem ;
Tasdemir, Arzu .
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2013, 14 (05) :3159-3161
[7]   Chemotherapy and Late Course Three Dimensional Conformal Radiotherapy for Treatment of Patients with Stage. Nonsmall Cell Lung Cancer [J].
Liu, Yang-Chen ;
Zhou, Shao-Bing ;
Gao, Fei ;
Ye, Hong-Xun ;
Zhao, Ying ;
Yi, Xiao-Xiang ;
Huang, Xin-En ;
Xiang, Jin .
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2013, 14 (04) :2663-2665
[8]   Potential Predictors of Sensitivity to Pemetrexed as First-line Chemotherapy for Patients with Advanced Non-Squamous NSCLCs [J].
Lu, Yan-Yan ;
Huang, Xin-En ;
Xu, Lin ;
Liu, De-Gan ;
Cao, Jie ;
Wu, Xue-Yan ;
Liu, Jin ;
Xiang, Jin .
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2013, 14 (03) :2005-2008
[9]  
MANNI JA, 1989, MEDICINA-BUENOS AIRE, V49, P105
[10]   Immunotherapy of cytotoxic T cell-resistant tumors by T helper 2 cells: An eotaxin and STAT6-dependent process [J].
Mattes, J ;
Hulett, M ;
Xie, W ;
Hogan, S ;
Rothenberg, ME ;
Foster, P ;
Parish, C .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (03) :387-393
12