Genetics of Atrial Fibrillation

被引：20

作者：

Lubitz, Steven A. ^{[3
,4
]}

Yi, B. Alexander ^{[2
,5
]}

Ellinor, Patrick T. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Cardiovasc Res Ctr, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

[3] Mt Sinai Sch Med, Cardiovasc Inst, New York, NY 10029 USA

[4] Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02446 USA

[5] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA

来源：

CARDIOLOGY CLINICS | 2009年 / 27卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Atrial fibrillation; Arrhythmia; Mutation; Gene; Genetics; OF-FUNCTION MUTATION; FAMILIAL AGGREGATION; KCNQ1; MUTATION; QT SYNDROME; POLYMORPHISM; RISK; ASSOCIATION; LONE; LOCUS; PITX2;

D O I：

10.1016/j.ccl.2008.09.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent studies of AF have identified mutations in a series of ion channels; however, these mutations appear to be relatively rare causes of AF. A genome-wide association study has identified novel variants on chromosome 4 associated with AF, although the mechanism of action for these variants remains unknown. Ultimately, a greater understanding of the genetics of AF should yield insights into novel pathways, therapeutic targets, and diagnostic testing for this common arrhythmia.

引用

页码：25 / +

页数：10

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