Genetics of Atrial Fibrillation

被引：20
|
作者：
Lubitz, Steven A. [3 ,4 ]
Yi, B. Alexander [2 ,5 ]
Ellinor, Patrick T. [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Cardiovasc Res Ctr, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
[3] Mt Sinai Sch Med, Cardiovasc Inst, New York, NY 10029 USA
[4] Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02446 USA
[5] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA
来源：
CARDIOLOGY CLINICS | 2009年 / 27卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Atrial fibrillation; Arrhythmia; Mutation; Gene; Genetics; OF-FUNCTION MUTATION; FAMILIAL AGGREGATION; KCNQ1; MUTATION; QT SYNDROME; POLYMORPHISM; RISK; ASSOCIATION; LONE; LOCUS; PITX2;
D O I：
10.1016/j.ccl.2008.09.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent studies of AF have identified mutations in a series of ion channels; however, these mutations appear to be relatively rare causes of AF. A genome-wide association study has identified novel variants on chromosome 4 associated with AF, although the mechanism of action for these variants remains unknown. Ultimately, a greater understanding of the genetics of AF should yield insights into novel pathways, therapeutic targets, and diagnostic testing for this common arrhythmia.
引用
收藏
页码：25 / +
页数：10
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