The involvement of non-B DNA structures in gross chromosomal rearrangements

被引：77

作者：

Bacolla, Albino ^{[1
]}

Wojciechowska, Marzena ^{[1
]}

Kosmider, Beata ^{[1
]}

Larson, Jacquelynn E. ^{[1
]}

Wells, Robert D. ^{[1
]}

机构：

[1] Texas A&M Univ Syst Hlth Sci Ctr, Texas Med Ctr, Ctr Genome Res, Inst Biosci & Technol, Houston, TX 77030 USA

来源：

DNA REPAIR | 2006年 / 5卷 / 9-10期

关键词：

non-B DNA conformations; gross deletions; hereditary diseases; low copy repeats (LCRs); triplet and tetranucleotide repeats;

D O I：

10.1016/j.dnarep.2006.05.032

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Non-B DNA conformations adopted by certain types of DNA sequences promote genetic instabilities, especially gross rearrangements including translocations. We conclude the following: (a) slipped (hairpin) structures, cruciforms, triplexes, tetraplexes and i-motifs, and left-handed Z-DNA are formed in chromosomes and elicit profound genetic consequences via recombination-repair, (b) repeating sequences, probably in their non-B conformations, cause gross genomic rearrangements (translocations, deletions, insertions, inversions, and duplications), and (c) these rearrangements are the genetic basis for numerous human diseases including polycystic kidney disease, adrenoleukodystrophy, follicular lymphomas, and spermatogenic failure. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1161 / 1170

页数：10

共 67 条

[31] Hotspots of homologous recombination in the human genome: not all homologous sequences are equal [J].