Contrastive Study of In Situ Sensing and Swabbing Detection Based on SERS-Active Gold Nanobush-PDMS Hybrid Film

Surface-enhanced Raman scattering (SERS) with fast and intuitive property has been extensively utilized in the field of food safety. Here, we demonstrated a novel noble metal-polymer hybrid film as a SERS substrate for food fungicide analysis. Benefiting from its transparency and flexibility, poly(dimethylsiloxane) (PDMS) film was chosen as a versatile supporting matrix to grow gold nanobushes (Au NBs) through a seed-mediated process. The as-prepared AuNB-PDMS hybrid film performed satisfactorily in testing 4-nitrothiophenol (4NTP) and exhibited an enhancement factor (EF) of 2.56 x 10(6). Moreover, the high sensitivity and elastic properties make the hybrid film a promising substrate in practical detection. Hence, the in situ sensing of TBZ, carbaryl, and their mixture was finally realized using the developed hybrid film, which exhibited higher sensitivity than that obtained by the swabbing method. This high-performance SERS substrate based on the flexible and transparent AuNB-PDMS hybrid film has great potential applications in the fast in situ monitoring of biochemical molecules.