Protective role of epigallocatechin-3-gallate in health and disease: A perspective

被引：126

作者：

Chowdhury, Animesh ^{[1
]}

Sarkar, Jaganmay ^{[1
]}

Chakraborti, Tapati ^{[1
]}

Pramanik, Pijush Kanti ^{[1
]}

Chakraborti, Sajal ^{[1
]}

机构：

[1] Univ Kalyani, Dept Biochem & Biophys, Kalyani 741235, W Bengal, India

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2016年 / 78卷

关键词：

EGCG; Cancer; Cardiovascular diseases; Diabetes; Neurodegenerative diseases; GREEN TEA POLYPHENOLS; HUMAN LUNG-CANCER; EPITHELIAL-MESENCHYMAL TRANSITION; PROSTATE-CANCER; DOWN-REGULATION; BLACK TEA; (-)-EPIGALLOCATECHIN GALLATE; ANTICARCINOGENIC ACTIVITY; CARDIOVASCULAR-DISEASE; 3T3-L1; PREADIPOCYTES;

D O I：

10.1016/j.biopha.2015.12.013

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Tea is the most popular beverages all over the world. Polyphenols are found ubiquitously in tea leaves and their regular consumption has been associated with a reduced risk of a number of chronic diseases including cancer, cardiovascular and neurodegenerative diseases. Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in tea leaves and received great attention due to their protective role in the prevention of the diseases. Rather than eliciting direct antioxidant effects, the mechanisms by which tea polyphenol express these beneficial properties appear to involve their interaction with cellular signaling pathways and related machinery that mediate cell function under both normal and pathological conditions. The central focus of this review is to provide an overview of the role that the major tea polyphenol, EGCG plays in preventing cancer, cardiovascular and neurodegenerative diseases. This review present epidemiological data, human intervention study findings, as well as animal and in vitro studies in support of these actions and delineates the molecular mechanism associated with the action of EGCG in ameliorating of such diseases. (C) 2015 Elsevier Masson SAS. All rights reserved.

引用

页码：50 / 59

页数：10