Coupling one-dimensional arterial blood flow to three-dimensional tissue perfusion models for in silico trials of acute ischaemic stroke

被引：31

作者：

Padmos, Raymond M. ^{[1
]}

Jozsa, Tamas, I ^{[2
]}

El-Bouri, Wahbi K. ^{[2
]}

Konduri, Praneeta R. ^{[3
,4
]}

Payne, Stephen J. ^{[2
]}

Hoekstra, Alfons G. ^{[1
]}

机构：

[1] Univ Amsterdam, Fac Sci, Inst Informat, Computat Sci Lab, Sci Pk 904, NL-1098 XH Amsterdam, Netherlands

[2] Univ Oxford, Inst Biomed Engn, Dept Engn Sci, Parks Rd, Oxford OX1 3PJ, England

[3] Amsterdam UMC, Locat AMC, Dept Radiol & Nucl Med, NL-1105 AZ Amsterdam, Netherlands

[4] Amsterdam UMC, Locat AMC, Biomed Engn & Phys, NL-1105 AZ Amsterdam, Netherlands

来源：

INTERFACE FOCUS | 2021年 / 11卷 / 01期

关键词：

one-dimensional blood flow model; perfusion territories; cerebral perfusion; acute ischaemic stroke; MIDDLE CEREBRAL-ARTERY; PULSATILITY INDEX; HUMAN BRAIN; STIFFNESS; TERRITORIES; BEHAVIOR; NETWORK; LIFE; 1-D;

D O I：

10.1098/rsfs.2019.0125

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An acute ischaemic stroke is due to the sudden blockage of an intracranial blood vessel by an embolized thrombus. In the context of setting up in silico trials for the treatment of acute ischaemic stroke, the effect of a stroke on perfusion and metabolism of brain tissue should be modelled to predict final infarcted brain tissue. This requires coupling of blood flow and tissue perfusion models. A one-dimensional intracranial blood flow model and a method to couple this to a brain tissue perfusion model for patient-specific simulations is presented. Image-based patient-specific data on the anatomy of the circle of Willis are combined with literature data and models for vessel anatomy not visible in the images, to create an extended model for each patient from the larger vessels down to the pial surface. The coupling between arterial blood flow and tissue perfusion occurs at the pial surface through the estimation of perfusion territories. The coupling method is able to accurately estimate perfusion territories. Finally, we argue that blood flow can be approximated as steady-state flow at the interface between arterial blood flow and tissue perfusion to reduce the cost of organ-scale simulations.

引用

页数：14