Synthesis, Characterization and Crystal Structure of Some Novel 1-(3,5-Dimethyl-1H-pyrazol-1-yl)-3-(substituted anilino)propan-1-ones

被引：2
|
作者：
Saeed, Aamer [1 ]
Hussain, Shahid [1 ]
Abbas, Naeem [1 ]
Bolte, Michael [2 ]
机构：
[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan
[2] Goethe Univ Frankfurt, Inst Anorgan Chem, D-60438 Frankfurt, Germany
来源：
CHINESE JOURNAL OF CHEMISTRY | 2009年 / 27卷 / 06期
关键词：
microwave-accelerated; 3,5-dimethylpyrazole; crystal structure; Michael addition; IDENTIFICATION;
D O I：
10.1002/cjoc.200990191
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Michael addition of some substituted anilines to methyl acrylate in acidic medium afforded the methyl 3-(substituted anilino)propionates (1a-1i), which on treatment with hydrazine hydrate in methanol were converted into corresponding 3-(substituted anilino) propionohydrazides (2a-2i) in good yields. Microwave irradiation of the latter with pentane-2,4-dione afforded 1-(3,5-dimethyl-1H-pyrazol-1-yl)-3-(substituted anilino)propan-1-ones(3a-3i) under solventless conditions. The structures were confirmed by spectroscopic data, elemental analyses and in case of the 3h by single crystal X-ray diffraction data.
引用
收藏
页码：1141 / 1147
页数：7
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