Genomics approaches in the understanding of Entamoeba histolytica virulence and gene expression regulation

被引：0

作者：

Lopez-Camarillo, Cesar ^{[1
]}

Guillen, Nancy ^{[2
,3
]}

Weber, Christian ^{[2
,3
]}

Orozco, Esther ^{[4
]}

Marchat, Laurence A. ^{[5
]}

机构：

[1] Univ Autonoma Ciudad Mexico, Mexico City, DF, Mexico

[2] Inst Pasteur, Unite Biol Cellulaire Parasitisme, Paris, France

[3] INSERM, U786, Paris, France

[4] CINVESTAV IPN, Dept Infect & Patogenesis Mol, Mexico City, DF, Mexico

[5] Inst Politecn Nacl, Escuela Nacl Med & Homeopatia, Programa Inst Biomed Mol, Mexico City, DF, Mexico

来源：

AFRICAN JOURNAL OF BIOTECHNOLOGY | 2009年 / 8卷 / 08期

关键词：

Entamoeba histolytica; amoebiasis; genome sequence; cDNA microarrays; genomic expression profiling; virulence; gene families; MESSENGER-RNA; HOMOLOGOUS RECOMBINATION; PARASITE; IDENTIFICATION; LECTIN; DEAD; REQUIREMENT; RESPONSES; NETWORKS; INVASION;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Entamoeba histolytica is the intestinal protozoan parasite responsible for amebic colitis and liver abscesses, which cause mortality in many developing countries. The sequencing of the parasite genome provides new insights into the cellular workings and genome evolution of this major human pathogen. Here, we reviewed recent advances in the efforts to understand virulence and gene expression regulation in E. histolytica by using genomic approaches based on microarray technology and bioinformatic analysis of genome sequence.

引用

页码：1363 / 1369

页数：7

共 40 条

[31] Recent insights into Entamoeba development: Identification of transcriptional networks associated with stage conversion [J].

Singh, Upinder ;

Ehrenkaufer, Gretchen M. .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2009, 39 (01) :41-47

[32] Entamoeba histolytica: Response of the parasite to metronidazole challenge on the levels of mRNA and protein expression [J].

Tazreiter, Margit ;

Leitsch, David ;

Hatzenbichler, Evelyn ;

Mair-Scorpio, Georg E. ;

Steinborn, Ralf ;

Schreiber, Martin ;

Duchene, Michael .

EXPERIMENTAL PARASITOLOGY, 2008, 120 (04) :403-410

[33] The Entamoeba histolytica genome:: primary structure and expression of proteolytic enzymes [J].

Tillack, Manuela ;

Biller, Laura ;

Irmer, Henriette ;

Freitas, Michelle ;

Gomes, Maria A. ;

Tannich, Egbert ;

Bruchhaus, Iris .

BMC GENOMICS, 2007, 8 (1)

[34]

VICENTEJOAO B, 2008, CELL MICROBIOL, V11, P51

[35]

WEBER C, 2008, MOL BIOCHEM PARASIT, DOI DOI 10.1016/

[36]

J.M0LBI0PARA.2008.12.005

[37] Stress by heat shock induces massive down regulation of genes and allows differential allelic expression of the Gal/GaINAc lectin in Entamoeba histolytica [J].

Weber, Christian ;

Guigon, Ghislaine ;

Bouchier, Christiane ;

Frangeul, Lionel ;

Moreira, Sandrine ;

Sismeiro, Odile ;

Gouyette, Catherine ;

Mirelman, David ;

Coppee, Jean Yves ;

Guillen, Nancy .

EUKARYOTIC CELL, 2006, 5 (05) :871-875

[38] Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function [J].

Yedavalli, VSRK ;

Neuveut, C ;

Chi, YH ;

Kleiman, L ;

Jeang, KT .

CELL, 2004, 119 (03) :381-392

[39] In silico analysis of EST and genomic sequences allowed the prediction of cis-regulatory elements for Entamoeba histolytica mRNA polyadenylation [J].

Zamorano, Absalom ;

Lopez-Camarillo, Cesar ;

Orozco, Esther ;

Weber, Christian ;

Guillen, Nancy ;

Marchat, Laurence A. .

COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2008, 32 (04) :256-263

[40] Tumor necrosis factor alpha is a key mediator of gut inflammation seen in amebic colitis in human intestine in the SCID mouse-human intestinal xenograft model of disease [J].

Zhang, Z ;

Mahajan, S ;

Zhang, XC ;

Stanley, SL .

INFECTION AND IMMUNITY, 2003, 71 (09) :5355-5359

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