Genomics approaches in the understanding of Entamoeba histolytica virulence and gene expression regulation

被引：0

作者：

Lopez-Camarillo, Cesar ^{[1
]}

Guillen, Nancy ^{[2
,3
]}

Weber, Christian ^{[2
,3
]}

Orozco, Esther ^{[4
]}

Marchat, Laurence A. ^{[5
]}

机构：

[1] Univ Autonoma Ciudad Mexico, Mexico City, DF, Mexico

[2] Inst Pasteur, Unite Biol Cellulaire Parasitisme, Paris, France

[3] INSERM, U786, Paris, France

[4] CINVESTAV IPN, Dept Infect & Patogenesis Mol, Mexico City, DF, Mexico

[5] Inst Politecn Nacl, Escuela Nacl Med & Homeopatia, Programa Inst Biomed Mol, Mexico City, DF, Mexico

来源：

AFRICAN JOURNAL OF BIOTECHNOLOGY | 2009年 / 8卷 / 08期

关键词：

Entamoeba histolytica; amoebiasis; genome sequence; cDNA microarrays; genomic expression profiling; virulence; gene families; MESSENGER-RNA; HOMOLOGOUS RECOMBINATION; PARASITE; IDENTIFICATION; LECTIN; DEAD; REQUIREMENT; RESPONSES; NETWORKS; INVASION;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Entamoeba histolytica is the intestinal protozoan parasite responsible for amebic colitis and liver abscesses, which cause mortality in many developing countries. The sequencing of the parasite genome provides new insights into the cellular workings and genome evolution of this major human pathogen. Here, we reviewed recent advances in the efforts to understand virulence and gene expression regulation in E. histolytica by using genomic approaches based on microarray technology and bioinformatic analysis of genome sequence.

引用

页码：1363 / 1369

页数：7

共 40 条

[1] Characterization of an Entamoeba histolytica high-mobility-group box protein induced during intestinal infection [J].

Abhyankar, Mayuresh M. ;

Hochreiter, Amelia E. ;

Hershey, Jessica ;

Evans, Clive ;

Zhang, Yan ;

Crasta, Oswald ;

Sobral, Bruno W. S. ;

Mann, Barbara J. ;

Petri, William A., Jr. ;

Gilchrist, Carol A. .

EUKARYOTIC CELL, 2008, 7 (09) :1565-1572

[2] Growth of the protozoan parasite Entamoeba histolytica in 5-azacytidine has limited effects on parasite gene expression [J].

Ali, Ibne Karim M. ;

Ehrenkaufer, Gretchen M. ;

Hackney, Jason A. ;

Singh, Upinder .

BMC GENOMICS, 2007, 8 (1)

[3]

[Anonymous], 1997, B WORLD HEALTH ORGAN, V75, P291

[4] The LINES and SINES of Entamoeba histolytica:: Comparative analysis and genomic distribution [J].

Bakre, AA ;

Rawal, K ;

Ramaswamy, R ;

Bhattacharya, A ;

Bhattacharya, S .

EXPERIMENTAL PARASITOLOGY, 2005, 110 (03) :207-213

[5] New insights into Entamoeba histolytica pathogenesis [J].

Baxt, Leigh A. ;

Singh, Upinder .

CURRENT OPINION IN INFECTIOUS DISEASES, 2008, 21 (05) :489-494

[6] Molecular players of homologous recombination in protozoan parasites: implications for generating antigenic variation [J].

Bhattacharyya, Mrinal Kanti ;

Norris, Douglas E. ;

Kumar, Nirbhay .

INFECTION GENETICS AND EVOLUTION, 2004, 4 (02) :91-98

[7] Chemotaxis of Entamoeba histolytica towards the pro-inflammatory cytokine TNF is based on PI3K signalling, cytoskeleton reorganization and the Galactose/N-acetylgalactosamine lectin activity [J].

Blazquez, Samantha ;

Guigon, Ghislaine ;

Weber, Christian ;

Syan, Sylvie ;

Sismeiro, Odile ;

Coppee, Jean-Yves ;

Labruyere, Elisabeth ;

Guillen, Nancy .

CELLULAR MICROBIOLOGY, 2008, 10 (08) :1676-1686

[8] UNUSUAL GENE ORGANIZATION IN THE PROTOZOAN PARASITE ENTAMOEBA-HISTOLYTICA [J].

BRUCHHAUS, I ;

LEIPPE, M ;

LIOUTAS, C ;

TANNICH, E .

DNA AND CELL BIOLOGY, 1993, 12 (10) :925-933

[9] Requirement of the DEAD-box protein Ded1p for messenger RNA translation [J].

Chuang, RY ;

Weaver, PL ;

Liu, Z ;

Chang, TH .

SCIENCE, 1997, 275 (5305) :1468-1471

[10] Structure and content of the Entamoeba histolytica genome [J].

Clark, C. G. ;

Alsmark, U. C. M. ;

Tazreiter, M. ;

Saito-Nakano, Y. ;

Ali, V. ;

Marion, S. ;

Weber, C. ;

Mukherjee, C. ;

Bruchhaus, I. ;

Tannich, E. ;

Leippe, M. ;

Sicheritz-Ponten, T. ;

Foster, P. G. ;

Samuelson, J. ;

Noel, C. J. ;

Hirt, R. P. ;

Embley, T. M. ;

Gilchrist, C. A. ;

Mann, B. J. ;

Singh, U. ;

Ackers, J. P. ;

Bhattacharya, S. ;

Bhattacharya, A. ;

Lohia, A. ;

Guillen, N. ;

Duchene, M. ;

Nozaki, T. ;

Hall, N. .

ADVANCES IN PARASITOLOGY, VOL 65, 2007, 65 :51-190

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