共 26 条
Characterization of poly(D,L-lactic-co-glycolic acid) based nanoparticulate system for enhanced delivery of antigens to dendritic cells
被引:188
作者:

Elamanchili, P
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alberta, Dent Pharm Ctr 3118, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada Univ Alberta, Dent Pharm Ctr 3118, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada

Diwan, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alberta, Dent Pharm Ctr 3118, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada Univ Alberta, Dent Pharm Ctr 3118, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada

Cao, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alberta, Dent Pharm Ctr 3118, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada Univ Alberta, Dent Pharm Ctr 3118, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada

Samuel, J
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alberta, Dent Pharm Ctr 3118, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada Univ Alberta, Dent Pharm Ctr 3118, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada
机构:
[1] Univ Alberta, Dent Pharm Ctr 3118, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada
来源:
关键词:
dendritic cells;
vaccine delivery;
nanospheres;
D O I:
10.1016/j.vaccine.2003.12.032
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Biodegradable nanoparticles made of poly(D,L-lactic acid-co-glycolic acid) (PLGA) copolymer were characterized for enhanced delivery of antigens to murine bone marrow derived dendritic cells (DCs) in vitro. PLGA nanoparticles were efficiently phagocytosed by the DCs (CD I I c, MHC class II+, CD86(+)) in culture, resulting in their intracellular localization. The efficiency of the uptake was influenced by the incubation time and nanoparticle concentration. DCs pulsed with PLGA nanoparticles containing an immunomodulator, monophosphoryl lipid A (MPLA), showed upregulation of surface expression of MHC class 11 and CD86 molecules. Delivery of a cancer-associated antigen (MUC1 mucin peptide: BLP25) and MPLA in PLGA nanoparticles was shown to be superior to their delivery in the soluble form for activation of naive T cells of normal and MUC1-transgenic mice. These results strongly suggest that PLGA nanoparticles provide an efficient vaccine delivery system for targeting DCs and the development of DC based cellular vaccines. (C) 2004 Elsevier Ltd. All rights reserved.
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页码:2406 / 2412
页数:7
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