New Insights on Intrahepatic Cholestasis of Pregnancy

被引：117

作者：

Floreani, Annarosa ^{[1
]}

Gervasi, Maria Teresa ^{[2
]}

机构：

[1] Univ Padua, Dept Surg Oncol & Gastroenterol, I-35128 Padua, Italy

[2] Azienda Ospedaliera, Dept Obstet & Gynecol, I-35128 Padua, Italy

来源：

CLINICS IN LIVER DISEASE | 2016年 / 20卷 / 01期

关键词：

Intrahepatic cholestasis of pregnancy; Itching; Bile salts; Ursodeoxycholic acid; Cholelithiasis; PHOSPHOLIPID-ASSOCIATED CHOLELITHIASIS; C VIRUS-INFECTION; URSODEOXYCHOLIC ACID; HEPATITIS-C; ABCB4; GENE; OBSTETRIC CHOLESTASIS; FETAL OUTCOMES; LIVER-DISEASE; EARLY-ONSET; MDR3;

D O I：

10.1016/j.cld.2015.08.010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Intrahepatic cholestasis of pregnancy (ICP) is characterized by maternal pruritus, and elevated serum transaminases and bile acids. Genetic defects in at least 6 canalicular transporters have been found. Association studies stress the variability of genotypes, different penetrance, and influence of environmental factors. Serum autotaxin is a sensitive, specific, and robust diagnostic marker. Elevated maternal bile acids correlate with fetal complications. Long-term sequelae for mothers include the gallstone risk and chronic liver disease. There is an association between ICP and hepatitis C. Current treatment is ursodeoxycholic acid, owing to benefits on pruritus, liver function, safety, and decreased rates of adverse effects.

引用

页码：177 / +

页数：14

共 75 条

[51] ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy
Müllenbach, R
Bennett, A
Tetlow, N
Patel, N
Hamilton, G
Cheng, F
Chambers, J
Howard, R
Taylor-Robinson, SD
Williamson, C
[J]. GUT, 2005, 54 (06) : 829 - 834
[52] Functional expression of the canalicular bile salt export pump of human liver
Noé, J
Stieger, B
Meier, PJ
[J]. GASTROENTEROLOGY, 2002, 123 (05) : 1659 - 1666
[53] Predicting fetal asphyxia in intrahepatic cholestasis of pregnancy
Oztekin, Deniz
Aydal, Ipek
Oztekin, Ozgur
Okcu, Sabriye
Borekci, Rengin
Tinar, Sivekar
[J]. ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2009, 280 (06) : 975 - 979
[54] First description of ABCB4 gene deletions in familial low phospholipid-associated cholelithiasis and oral contraceptives-induced cholestasis
Pasmant, Eric
Goussard, Philippe
Baranes, Laetitia
Laurendeau, Ingrid
Quentin, Samuel
Ponsot, Philippe
Consigny, Yann
Farges, Olivier
Condat, Bertrand
Vidaud, Dominique
Vidaud, Michel
Chen, Jian-Min
Parfait, Beatrice
[J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 2012, 20 (03) : 277 - 282
[55] Intra-hepatic cholestasis of pregnancy in hepatitis C virus infection
Paternoster, DM
Fabris, F
Palù, G
Santarossa, C
Bracciante, R
Snijders, D
Floreani, A
[J]. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2002, 81 (02) : 99 - 103
[56] Genotype-Phenotype Relationships in the Low-Phospholipid-Associated Cholelithiasis Syndrome: A Study of 156 Consecutive Patients
Poupon, Raoul
Rosmorduc, Olivier
Boelle, Pierre Yves
Chretien, Yves
Corpechot, Christophe
Chazouilleres, Olivier
Housset, Chantal
Barbu, Veronique
[J]. HEPATOLOGY, 2013, 58 (03) : 1105 - 1110
[57] The risk of infant and fetal death by each additional week of expectant management in intrahepatic cholestasis of pregnancy by gestational age
Puljic, Anela
Kim, Elissa
Page, Jessica
Esakoff, Tania
Shaffer, Brian
LaCoursiere, Daphne Y.
Caughey, Aaron B.
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2015, 212 (05) : 667.e1 - 667.e5
[58] Qi Hong-bo, 2004, Zhonghua Fu Chan Ke Za Zhi, V39, P14
[59] FETAL COMPLICATIONS OF OBSTETRIC CHOLESTASIS
REID, R
IVEY, KJ
RENCORET, RH
STOREY, B
[J]. BRITISH MEDICAL JOURNAL, 1976, 1 (6014) : 870 - 872
[60] Selenium, zinc and copper plasma levels in intrahepatic cholestasis of pregnancy, in normal pregnancies and in healthy individuals, in Chile
Reyes, H
Báez, ME
González, MC
Hernández, I
Palma, J
Ribalta, J
Sandoval, L
Zapata, R
[J]. JOURNAL OF HEPATOLOGY, 2000, 32 (04) : 542 - 549

← 1 2 3 4 5 6 7 8 →