New Insights on Intrahepatic Cholestasis of Pregnancy

被引：115
作者：
Floreani, Annarosa [1 ]
Gervasi, Maria Teresa [2 ]
机构：
[1] Univ Padua, Dept Surg Oncol & Gastroenterol, I-35128 Padua, Italy
[2] Azienda Ospedaliera, Dept Obstet & Gynecol, I-35128 Padua, Italy
来源：
CLINICS IN LIVER DISEASE | 2016年 / 20卷 / 01期
关键词：
Intrahepatic cholestasis of pregnancy; Itching; Bile salts; Ursodeoxycholic acid; Cholelithiasis; PHOSPHOLIPID-ASSOCIATED CHOLELITHIASIS; C VIRUS-INFECTION; URSODEOXYCHOLIC ACID; HEPATITIS-C; ABCB4; GENE; OBSTETRIC CHOLESTASIS; FETAL OUTCOMES; LIVER-DISEASE; EARLY-ONSET; MDR3;
D O I：
10.1016/j.cld.2015.08.010
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Intrahepatic cholestasis of pregnancy (ICP) is characterized by maternal pruritus, and elevated serum transaminases and bile acids. Genetic defects in at least 6 canalicular transporters have been found. Association studies stress the variability of genotypes, different penetrance, and influence of environmental factors. Serum autotaxin is a sensitive, specific, and robust diagnostic marker. Elevated maternal bile acids correlate with fetal complications. Long-term sequelae for mothers include the gallstone risk and chronic liver disease. There is an association between ICP and hepatitis C. Current treatment is ursodeoxycholic acid, owing to benefits on pruritus, liver function, safety, and decreased rates of adverse effects.
引用
收藏
页码：177 / +
页数：14
相关论文
共 75 条
  • [1] [Anonymous], 2015, PLOS MED, DOI DOI 10.1016/J.AJ0G.2014.07.026.25046809
  • [2] Arrese Marco, 2006, Ann Hepatol, V5, P202
  • [3] Efficacy of Ursodeoxycholic Acid in Treating Intrahepatic Cholestasis of Pregnancy: A Meta-analysis
    Bacq, Yannick
    Sentilhes, Loic
    Reyes, Humberto B.
    Glantz, Anna
    Kondrackiene, Jurate
    Binder, Tomas
    Nicastri, Pier Luigi
    Locatelli, Anna
    Floreani, Annarosa
    Hernandez, Ismael
    Di Martino, Vincent
    [J]. GASTROENTEROLOGY, 2012, 143 (06) : 1492 - 1501
  • [4] Intrahepatic cholestasis of pregnancy is not associated with stillbirth in an Australian maternity population
    Bannister-Tyrrell, Melanie
    Ford, Jane B.
    Morris, Jonathan M.
    Roberts, Christine L.
    [J]. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2014, 176 : 204 - 205
  • [5] Intrahepatic cholestasis of pregnancy with concomitant hepatitis C virus infection, Joan C. Edwards SOM, Marshall University
    Belay, Tilahun
    Woldegiorgis, Hailegiorgis
    Gress, Todd
    Rayyan, Yaser
    [J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2015, 27 (04) : 372 - 374
  • [6] Berg B, 1996, ACTA OBSTET GYNECOL, V175, P957
  • [7] Unusual case of severe cholestasis of pregnancy with early onset, improved by ursodeoxycholic acid administration
    Brites, D
    Rodrigues, CMP
    Cardoso, MD
    Graça, LM
    [J]. EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1998, 76 (02): : 165 - 168
  • [8] Primary Dermatologic Findings With Early-Onset Intrahepatic Cholestasis of Pregnancy
    Chao, Tamara T.
    Sheffield, Jeanne S.
    [J]. OBSTETRICS AND GYNECOLOGY, 2011, 117 (02) : 456 - 458
  • [9] NR1H4 analysis in patients with progressive familial intrahepatic cholestasis, drug-induced cholestasis or intrahepatic cholestasis of pregnancy unrelated to ATP8B1, ABCB11 and ABCB4 mutations
    Davit-Spraul, Anne
    Gonzales, Emmanuel
    Jacquemin, Emmanuel
    [J]. CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2012, 36 (06) : 569 - 573
  • [10] The Spectrum of Liver Diseases Related to ABCB4 Gene Mutations: Pathophysiology and Clinical Aspects
    Davit-Spraul, Anne
    Gonzales, Emmanuel
    Baussan, Christiane
    Jacquemin, Emmanuel
    [J]. SEMINARS IN LIVER DISEASE, 2010, 30 (02) : 134 - 146
12345678