New Insights on Intrahepatic Cholestasis of Pregnancy

被引：122

作者：

Floreani, Annarosa ^{[1
]}

Gervasi, Maria Teresa ^{[2
]}

机构：

[1] Univ Padua, Dept Surg Oncol & Gastroenterol, I-35128 Padua, Italy

[2] Azienda Ospedaliera, Dept Obstet & Gynecol, I-35128 Padua, Italy

来源：

CLINICS IN LIVER DISEASE | 2016年 / 20卷 / 01期

关键词：

Intrahepatic cholestasis of pregnancy; Itching; Bile salts; Ursodeoxycholic acid; Cholelithiasis; PHOSPHOLIPID-ASSOCIATED CHOLELITHIASIS; C VIRUS-INFECTION; URSODEOXYCHOLIC ACID; HEPATITIS-C; ABCB4; GENE; OBSTETRIC CHOLESTASIS; FETAL OUTCOMES; LIVER-DISEASE; EARLY-ONSET; MDR3;

D O I：

10.1016/j.cld.2015.08.010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Intrahepatic cholestasis of pregnancy (ICP) is characterized by maternal pruritus, and elevated serum transaminases and bile acids. Genetic defects in at least 6 canalicular transporters have been found. Association studies stress the variability of genotypes, different penetrance, and influence of environmental factors. Serum autotaxin is a sensitive, specific, and robust diagnostic marker. Elevated maternal bile acids correlate with fetal complications. Long-term sequelae for mothers include the gallstone risk and chronic liver disease. There is an association between ICP and hepatitis C. Current treatment is ursodeoxycholic acid, owing to benefits on pruritus, liver function, safety, and decreased rates of adverse effects.

引用

页码：177 / +

页数：14

共 75 条

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[2]

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