Pancreatic biomarkers: Could they be the answer?

被引：7

作者：

Lamarca, Angela ^{[1
,2
]}

Feliu, Jaime ^{[2
]}

机构：

[1] Christie NHS Fdn Trust, Dept Med Oncol, Manchester M20 4BX, Lancs, England

[2] La Paz Univ Hosp, Dept Med Oncol, Madrid 28046, Spain

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 24期

关键词：

Pancreatic adenocarcinoma; Biomarkers; Diagnosis; Prognostic; Predictive; Treatment; TISSUE GROWTH-FACTOR; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER-1; GENETIC-BASIS; ADJUVANT CHEMOTHERAPY; DUCTAL ADENOCARCINOMA; NAB-PACLITAXEL; MOUSE MODEL; GEMCITABINE TRANSPORT; THYMIDYLATE SYNTHASE; SPARC EXPRESSION;

D O I：

10.3748/wjg.v20.i24.7819

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatic ductal adenocarcinoma (PDA) is known for its poor prognosis. Most of the patients are diagnosed with advanced stages, when no curative treatment is available. Currently, despite extensive clinical research on PDA, the median overall survival remains short. Diagnosis delay and primary chemo-resistance due to its intrinsic biological nature may explain the challenges to improve our results. Our knowledge about the molecular biology of PDA has exponentially increased during the last decades and its use for the development of biomarkers could help to reach better results in the clinical setting. These biomarkers could be the clue for the improvement in PDA clinical research by earlier detection strategies with diagnostic biomarkers, and by an individualization of treatment approach with prognostic and predictive biomarkers. This review summarizes the current knowledge about the molecular biology of PDA and the status of the most important prognostic and predictive biomarkers. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

引用

页码：7819 / 7829

页数：11

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