Association study of the 5-hydroxytryptamine6 receptor gene in Alzheimer's disease

被引：19
作者：
Orlacchio, A
Kawarai, T
Paciotti, E
Stefani, A
Orlacchio, A
Sorbi, S
St George-Hyslop, PH
Bernardi, G
机构：
[1] IRCCS, Neurogenet Lab, I-00179 Rome, Italy
[2] Univ Roma Tor Vergata, Osped S Eugenio Neurol, Dipartimento Neurosci, I-00144 Rome, Italy
[3] Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON M5S 3H2, Canada
[4] Toronto Hosp, Dept Med, Toronto, ON M5T 2S8, Canada
[5] Univ Perugia, Dipartiemnto Sci Biochim & Biotecnol Mol, I-06126 Perugia, Italy
[6] Univ Florence, Dipartimento Sci Neurol & Psichiat, I-50134 Florence, Italy
来源：
NEUROSCIENCE LETTERS | 2002年 / 325卷 / 01期
关键词：
Alzheimer's disease; single nucleotide polymorphism; 5-hydroxytryptamine(6) receptor gene;
D O I：
10.1016/S0304-3940(02)00221-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Serotonergic (5-hydroxytryptamine; 5-HT) transmission has been implicated in the pathogenesis of Alzheimer's disease (AD). A coding single nucleotide polymorphism 267 (C/T) in the 5-HT6 receptor gene was previously reported as a susceptibility factor for AD. An extensive replication study was performed using our data set including sporadic and familial cases. No significant association between the 5-HT6 receptor gene and AD was obtained with or without the stratification of apolipoprotein E epsilon4 status. Our result suggests that the 267C allele of the 5-HT6 receptor gene may not be a genetic risk factor for AD. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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页码：13 / 16
页数：4
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