Chemoenzymatic synthesis of fluorescent N-ras lipopeptides and their use in membrane localization studies in vivo

被引:31
|
作者
Waldmann, H
Schelhaas, M
Nagele, E
Kuhlmann, J
Wittinghofer, A
Schroeder, H
Silvius, JR
机构
[1] MAX PLANCK INST MOL PHYSIOL,D-44026 DORTMUND,GERMANY
[2] MCGILL UNIV,DEPT BIOCHEM,MONTREAL,PQ H3G 1Y6,CANADA
来源
关键词
D O I
10.1002/anie.199722381
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:2238 / 2241
页数:4
相关论文
共 50 条
  • [1] Chemoenzymatic synthesis of N-Ras lipopeptides
    Nägele, E
    Schelhaas, M
    Kuder, N
    Waldmann, H
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (28) : 6889 - 6902
  • [2] Synthesis of characteristic lipopeptides of the human N-Ras protein and their evaluation as possible inhibitors of protein farnesyl transferase
    Stober, P
    Schelhaas, M
    Nagele, E
    Hagenbuch, P
    Retey, J
    Waldmann, H
    BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (01) : 75 - 83
  • [3] Synthesis of the palmitoylated and prenylated C-terminal lipopeptides of the human R- and N-ras proteins
    Schmittberger, T
    Waldmann, H
    BIOORGANIC & MEDICINAL CHEMISTRY, 1999, 7 (05) : 749 - 762
  • [4] PURIFICATION AND CHARACTERIZATION OF THE PROTEIN ENCODED BY THE ACTIVATED HUMAN N-RAS GENE AND ITS MEMBRANE LOCALIZATION
    GRAND, RJA
    SMITH, KJ
    GALLIMORE, PH
    ONCOGENE, 1987, 1 (03) : 305 - 314
  • [5] Activated N-ras oncogene and N-ras proto-oncogene act through the same pathway for in vivo tumorigenesis
    Mangues, R
    Symmans, WF
    Lu, SY
    Schwartz, S
    Pellicer, A
    ONCOGENE, 1996, 13 (05) : 1053 - 1063
  • [6] Chemoenzymatic synthesis of biotinylated Ras peptides and their use in membrane binding studies of lipidated model proteins by surface plasmon resonance
    Schelhaas, M
    Nägele, E
    Kuder, N
    Bader, B
    Kuhlmann, J
    Wittinghofer, A
    Waldmann, H
    CHEMISTRY-A EUROPEAN JOURNAL, 1999, 5 (04) : 1239 - 1252
  • [7] Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo
    Mark Hamilton
    Alan Wolfman
    Oncogene, 1998, 16 : 1417 - 1428
  • [8] Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo
    Hamilton, M
    Wolfman, A
    ONCOGENE, 1998, 16 (11) : 1417 - 1428
  • [9] INHIBITION OF THE MEMBRANE LOCALIZATION OF P21 RAS PROTEINS BY LOVASTATIN IN TUMOR-CELLS POSSESSING A MUTATED N-RAS GENE
    GIRGERT, R
    MARINI, P
    JANESSA, A
    BRUCHELT, G
    TREUNER, J
    SCHWEIZER, P
    ONCOLOGY, 1994, 51 (04) : 320 - 322
  • [10] MECHANISM OF GTP HYDROLYSIS BY P21(N-RAS) CATALYZED BY GAP - STUDIES WITH A FLUORESCENT GTP ANALOG
    MOORE, KJM
    WEBB, MR
    ECCLESTON, JF
    BIOCHEMISTRY, 1993, 32 (29) : 7451 - 7459