Chemical Composition, Biological and Cytotoxic Activities of Plant Extracts and Compounds Isolated from Ferula lutea

被引：22

作者：

Znati, Mansour ^{[1
,2
]}

Ben Jannet, Hichem ^{[2
]}

Cazaux, Sylvie ^{[1
]}

Bouajila, Jalloul ^{[1
]}

机构：

[1] Univ Toulouse 3, Univ Toulouse, Fac Pharm Toulouse, Lab IMRCP UMR CNRS 5623, F-31062 Toulouse, France

[2] Univ Monastir, Lab Chim Heterocycl Prod Nat & Reactivite CHPNR, Equipe Chim Med & Prod Nat, Fac Sci Monastir,Dept Chim, Monastir 5019, Tunisia

来源：

MOLECULES | 2014年 / 19卷 / 03期

关键词：

Ferula lutea; (+)-Z-deltoin; (-)-E-deltoin; antioxidant; antiacetylcholinesterase; antimicrobial; antidiabetic; cytotoxic; allelopathic; ANTIOXIDANT ACTIVITY; COUMARINS; OIL; CONSTITUENTS; FRUITS; ROOTS; L;

D O I：

10.3390/molecules19032733

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present work describes the phytochemical study on Ferula lutea flowers. Total phenolics and flavonoids of the n-butanol and ethyl acetate extracts were quantified (phenolics [40.68-52.29 mg gallic acid equivalent/g of dry weight], flavonoids [12.38-14.72 mg quercitin/g dry weight]). Two diastereoisomers were isolated and identified using spectroscopic techniques (1D, 2D NMR and GC-MS). The extracts and diastereoisomers were tested for antioxidant, antiacetylcholinesterase, antimicrobial, antidiabectic, cytotoxic (leukemia cell line) activities and allelopathic potentialities. The strongest antioxidant activity was obtained for the ethyl acetate extract (IC50 = 12.8 +/- 1.29 mu g/mL). The two extracts exhibited high antidiabetic activity (54.1 and 52.1% at 40 mu g/mL).

引用

页码：2733 / 2747

页数：15

共 37 条

[1]

Abedi D, 2008, RES PHARM SCI, V3, P41

[2]

Abyshev A Z., 1984, Chem. Nat. Compd, V20, P230

[3] Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines [J].