A Phase 1 Trial of MEC (Mitoxantrone, Etoposide, Cytarabine) in Combination with Ixazomib (MLN9708) for Relapsed/Refractory Acute Myeloid Leukemia (AML)

被引:0
|
作者
Advani, Anjali S. [1 ]
Cooper, Brenda [2 ]
Elson, Paul [3 ]
Mukherjee, Sudipto [4 ]
Fensterl, Jaime [5 ]
Gerds, Aaron T. [6 ]
Caimi, Paolo F. [2 ]
Tomlinson, Ben K. [2 ]
Malek, Ehsan [7 ]
Little, Jane A. [8 ]
Rush, Mary Lynn [9 ]
Bogati, Samjhana [10 ]
Parsons, Eric [9 ]
Kane, Donna [11 ]
Carraway, Hetty E. [4 ]
Nazha, Aziz [6 ]
Hamilton, Betty K. [6 ]
Sobecks, Ronald [12 ]
Bevier, Barbara [9 ]
Goebel, Christopher [9 ]
Zimmerman, Cassie [9 ]
Nielsen, Alek D. [13 ]
Hirsch, Cassandra M. [13 ]
Maciejewski, Jaroslaw P. [13 ]
Kalaycio, Matt [4 ]
deLima, Marcos [14 ]
Jacobberger, James [15 ]
Woost, Philip [15 ]
Sekeres, Mikkael A. [4 ,16 ]
机构
[1] Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Leukemia Program, Cleveland, OH USA
[2] Univ Hosp Case Med Ctr, Adult Hematol Malignancies & Stem Cell Transplant, Seidman Canc Ctr, Cleveland, OH USA
[3] Cleveland Clin, Quantitat Hlth Sci, Cleveland, OH USA
[4] Cleveland Clin, Taussig Canc Inst Leukemia Program, Cleveland, OH USA
[5] Cleveland Clin, Taussig Canc Inst, Leukemia Program, Cleveland, OH USA
[6] Cleveland Clin, Taussig Canc Inst, Cleveland, OH USA
[7] Univ Hosp Case Med Ctr, Cleveland, OH USA
[8] Case Western Reserve Univ Univ Hosp Seidman Canc, Div Hematol Oncol, Cleveland, OH USA
[9] Cleveland Clin Leukemia Program, Taussig Canc Inst, Cleveland, OH USA
[10] Cleveland Clin Taussig Canc Inst, Taussig Canc Inst Leukemia Program, Cleveland, OH USA
[11] Univ Hosp Cleveland, Seidman Canc Ctr, Cleveland, OH USA
[12] Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Blood & Marrow Transplant Program, Cleveland, OH USA
[13] Cleveland Clin, Taussig Canc Inst, Dept Translat Hematol & Oncol Res, Cleveland, OH USA
[14] Univ Hosp, Adult Hematol Malignancies & Stem Cell Transplant, Seidman Canc Ctr, Cleveland, OH USA
[15] Case Western Reserve Univ, Cleveland, OH USA
[16] Cleveland Clin, Dept Hematol & Med Oncol, Leukemia Program, Cleveland, OH USA
关键词
D O I
10.1182/blood.V128.22.4065.4065
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
4065
引用
收藏
页数:5
相关论文
共 50 条
  • [21] A Single Institution Comparison of Mitoxantrone, Etoposide and Cytarabine (MEC) Vs High-Dose Cytarabine and Mitoxantrone (Ara-C Couplets) for Treatment of Patients with Relapsed or Refractory Acute Myeloid Leukemia
    Christian, Sonia
    Patel, Pritesh
    Esen, Aysenur
    Khan, Irum
    Sweiss, Karen
    Ghanem, Fares
    Sequeira, Christopher A.
    Shergill, Ardaman
    Quigley, John G.
    BLOOD, 2017, 130
  • [22] Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Identifies Novel Biomarkers to Inform Mitoxantrone, Etoposide, and Cytarabine (MEC)-Based Combination Therapy in Refractory & Relapsed Acute Myeloid Leukemia (AML) Patients
    Marcucci, Guido
    Kumar, Ansu
    Castro, Michael
    Grover, Himanshu
    Patil, Vivek
    Alam, Aftab
    Azam, Humera
    Mohapatra, Subrat
    Tyagi, Anuj
    Kumari, Pallavi
    Prasad, Samiksha Avinash
    Nair, Prashant Ramachandran
    Lunkad, Neelesh
    Joseph, Vishwas
    Poornachandra, G.
    Chauhan, Jyoti
    Basu, Sayani
    Behura, Liptimayee
    Ghosh, Adity
    Husain, Zakir
    Mandal, Rema
    raman, Rahul K.
    Patel, Sanjana
    Mundkur, Nirjhar
    Christie, James
    Macpherson, Michele Dundas
    Howard, Scott C.
    BLOOD, 2021, 138
  • [23] A PEDIATRIC-ONCOLOGY-GROUP (POG) PHASE-II TRIAL OF MITOXANTRONE, ETOPOSIDE AND CYCLOSPORINE A (MEC) THERAPY FOR RELAPSED AND REFRACTORY ACUTE MYELOGENOUS LEUKEMIA (AML)
    DAHL, G
    DUNUSSI, K
    MOGUL, M
    BROPHY, N
    LOWE, K
    GRIER, H
    SIKIC, B
    WEINSTEIN, H
    ARCECI, R
    BLOOD, 1993, 82 (10) : A195 - A195
  • [24] Outcome of etoposide and mitoxantrone for relapsed or refractory acute myeloid leukemia (RR-AML) in the modern era.
    Bowman, Zelia Ramone Karema
    Caddell, Ryan James
    Kanate, Abraham Sebastian
    Shillingburg, Alex
    Shah, Nilay Arvind
    Craig, Michael
    Cumpston, Aaron
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [25] A Multi-Institution Comparison of Mitoxantrone, Etoposide and Cytarabine (MEC) Vs High-Dose Cytarabine and Mitoxantrone (Ara-C Couplets) Therapy for Patients with Relapsed or Refractory Acute Myeloid Leukemia
    Christian, Sonia
    Patel, Pritesh
    Agrawal, Vaibhav
    Griffin, Shawn
    Cahill, Kirk
    Khan, Irum
    Sweiss, Karen
    Shergill, Ardaman
    Calip, Gregory Sampang
    Stock, Wendy
    Odenike, Olatoyosi
    Konig, Heiko
    Quigley, John G.
    BLOOD, 2018, 132
  • [26] Mitoxantrone, Etoposide, and Cytarabine (MEC) Following Epigenetic Priming with Decitabine in Adults with Relapsed/Refractory Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS): Final Results from a Phase 1/2 Study
    Halpern, Anna B.
    Buckley, Sarah A.
    Othus, Megan
    Huebner, Emily M.
    Orlowski, Kaysey F.
    Scott, Bart L.
    Perdue, Andrea M.
    Smith, Heather A.
    Becker, Pamela S.
    Hendrie, Paul C.
    Cassone, Stephanie
    Chen, Tara L.
    Stirewalt, Derek L.
    Estey, Elihu H.
    Walter, Roland B.
    BLOOD, 2016, 128 (22)
  • [27] A multi-institutional comparison of mitoxantrone, etoposide, and cytarabine vs high-dose cytarabine and mitoxantrone therapy for patients with relapsed or refractory acute myeloid leukemia
    Christian, Sonia
    Arain, Saad
    Patel, Pritesh
    Khan, Irum
    Calip, Gregory S.
    Agrawal, Vaibhav
    Sweiss, Karen
    Griffin, Shawn
    Cahill, Kirk
    Konig, Heiko
    Esen, Aysenur
    Shergill, Ardaman
    Odenike, Olatoyosi
    Stock, Wendy
    Quigley, John G.
    AMERICAN JOURNAL OF HEMATOLOGY, 2020, 95 (08) : 937 - 943
  • [28] The Use of Clofarabine and Cytarabine Combination (CLARA) As Salvage Therapy for Relapsed and/or Refractory Acute Myeloid Leukemia (AML)
    Leung, Anskar Y. H.
    Tse, Eric
    Liu, Herman S. Y.
    Sim, Joycelyn
    Kho, Bonnie C. S.
    Yip, Sze-Fai
    Lee, Harold K. K.
    Kwong, Yok Lam
    BLOOD, 2012, 120 (21)
  • [29] Relapsed and Refractory Acute Myeloid Leukemia (AML) Treated with AS1411 and Cytarabine: A Randomized Phase II Trial.
    Stuart, Robert Kenneth
    Acton, Gary
    BLOOD, 2008, 112 (11) : 676 - 676
  • [30] Combination of topotecan with cytarabine or etoposide in patients with refractory or relapsed acute myeloid leukemia: Results of a randomized phase I/II study
    Vey, N
    Kantarjian, H
    Beran, M
    O'Brien, S
    Cortes, J
    Koller, C
    Estey, E
    INVESTIGATIONAL NEW DRUGS, 1999, 17 (01) : 89 - 95