Homocysteine and cardiovascular disease: Current evidence and future prospects

被引：171

作者：

Mangoni, AA ^{[1
]}

Jackson, SHD ^{[1
]}

机构：

[1] Kings Coll London, Guys Kings & St Thomas Sch Med, Dept Hlth Care Elderly, London WC2R 2LS, England

来源：

AMERICAN JOURNAL OF MEDICINE | 2002年 / 112卷 / 07期

关键词：

D O I：

10.1016/S0002-9343(02)01021-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hyperhomocysteinemia is an independent risk factor for cardiovascular disease, Despite the well-known effectiveness of vitamin supplementation in reducing homocysteine levels, it is not known whether lowering of homocysteine levels is associated with a reduction in cardiovascular morbidity and mortality. The aim of this review is to discuss the epidemiologic evidence about the relation between homocysteine and cardiovascular disease, the pathophysiologic mechanisms responsible for the deleterious vascular and hemostatic effects of homocysteine, and studies of the potential benefits of homocysteine-lowering therapy.

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页码：556 / 565

页数：10

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