Visible-Light-Induced, Palladium-Catalyzed 1,4-Difunctionalization of 1,3-Dienes with Bromodifluoroacetamides

被引：35

作者：

Liu, Zhi-Lin ^{[1
]}

Ye, Zhi-Peng ^{[1
]}

Chen, Yi-Xuan ^{[1
]}

Zheng, Yu ^{[1
]}

Xie, Zhen-Zhen ^{[1
]}

Guan, Jian-Ping ^{[1
]}

Xiao, Jun-An ^{[2
]}

Chen, Kai ^{[1
]}

Xiang, Hao-Yue ^{[1
,3
]}

Yang, Hua ^{[1
]}

机构：

[1] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China

[2] Nanning Normal Univ, Guangxi Key Lab Nat Polymer Chem & Phys, Nanning 530001, Guangxi, Peoples R China

[3] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 03期

基金：

中国国家自然科学基金;

关键词：

HECK-TYPE REACTIONS; ENANTIOSELECTIVE 1,2-DIFUNCTIONALIZATION; MULTICOMPONENT REACTIONS; ALKYL-HALIDES; DRIVEN; FLUORINE; CASCADE;

D O I：

10.1021/acs.orglett.1c04293

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly modular 1,4-difunctionalization of 1,3-dienes with bromodifluoroacetamides and sulfinates/amines through a photoinduced palladium-catalyzed radical relay process is described herein. This developed protocol offers a facile and general route to access a variety of value-added CF2-incorporated alkenes in moderate to good yields. The versatility and flexibility of this approach have been well illustrated by readily accessible starting materials, synthetic convenience, and wide functional group compatibility.

引用

页码：924 / 928

页数：5

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