Pre-Stroke Frailty and Stroke Severity in Elderly Patients with Acute Stroke

被引：42
作者：
Kanai, Masashi [1 ,4 ,6 ]
Noguchi, Madoka [2 ]
Kubo, Hiroki [2 ]
Nozoe, Masafumi [1 ]
Kitano, Tamami [2 ,3 ,6 ]
Izawa, Kazuhiro P. [4 ,6 ]
Mase, Kyoshi [1 ]
Shimada, Shinichi [4 ,5 ,6 ]
机构：
[1] Konan Womens Univ, Fac Nursing & Rehabil, Dept Phys Therapy, Kobe, Hyogo, Japan
[2] Itami Kousei Neurosurg Hosp, Dept Rehabil, 1-300-1 Nishino, Itami, Hyogo 6640028, Japan
[3] Kobe Univ, Sch Med, Fac Hlth Sci, Dept Phys Therapy, Kobe, Hyogo, Japan
[4] Kobe Univ, Grad Sch Hlth Sci, Dept Publ Hlth, Kobe, Hyogo, Japan
[5] Itami Kousei Neurosurg Hosp, Dept Neurosurg, Itami, Hyogo, Japan
[6] Cardiovasc Stroke Renal Project CRP, Kobe, Hyogo, Japan
来源：
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | 2020年 / 29卷 / 12期
关键词：
Stroke; Frailty; Severity; Risk factor; Elderly; ISCHEMIC-STROKE; OLDER-ADULTS; MORTALITY; SURVIVAL; JAPAN;
D O I：
10.1016/j.jstrokecerebrovasdis.2020.105346
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Objective: Frailty is a major problem in super-aged societies. Because frailty assessments are largely unstudied in acute stroke settings, few reports have evaluated the association between pre-stroke frailty and stroke severity. The aim of this study was to determine the association between pre-stroke frailty and stroke severity in elderly patients with acute stroke. Materials and Methods: This cross-sectional study enrolled consecutive elderly patients with acute stroke. We assessed stroke severity with the National Institutes of Stroke Scale (NIHSS), and pre-stroke frailty with a Frailty Screening Index in elderly patients with acute stroke. Patients were divided according to their Frailty Screening Index: the robust group, pre-frailty group, and frailty group. Multiple linear regression analysis was used to determine whether pre-stroke frailty was independently associated with NIHSS score. Results: In total, 234 elderly patients with acute stroke (age: 75.7 years; 149 men, 85 women) were enrolled in this study. Of these, the robust group comprised 76 patients, the pre-frailty group comprised 129 patients, and the frailty group comprised 29 patients. The prevalence of pre-stroke frailty was 12.4%. Multiple linear regression analysis showed that prestroke pre-frailty and frailty were significantly associated with NIHSS score (prefrailty; beta = 1.191, P =.005, frailty; beta = 1.708, P =.009). Conclusions: The present study indicated that the pre-stroke frailty was significantly associated with stroke severity in elderly patients with acute stroke. Additional study is needed to clarify the association between pre-stroke frailty and post-stroke prognosis.
引用
收藏
页数：5
相关论文
共 22 条
[11]   The Impact of Physical Activity Before and After Stroke on Stroke Risk and Recovery: a Narrative Review [J].
Kramer, Sharon Flora ;
Hung, Stanley Hughwa ;
Brodtmann, Amy .
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2019, 19 (06)
[12]   Changes in frailty status in a community-dwelling cohort of older adults: The VERISAUDE study [J].
Lorenzo-Lopez, Laura ;
Lopez-Lopez, Rocks ;
Maseda, Ana ;
Bujan, Ana ;
Rodriguez-Villamil, Jose L. ;
Millan-Calenti, Jose C. .
MATURITAS, 2019, 119 :54-60
[13]   IMPROVED RELIABILITY OF THE NIH STROKE SCALE USING VIDEO TRAINING [J].
LYDEN, P ;
BROTT, T ;
TILLEY, B ;
WELCH, KMA ;
MASCHA, EJ ;
LEVINE, S ;
HALEY, EC ;
GROTTA, J ;
MARLER, J .
STROKE, 1994, 25 (11) :2220-2226
[14]   Prestroke physical activity could influence acute stroke severity (part of PAPSIGOT) [J].
Reinholdsson, Malin ;
Palstam, Annie ;
Sunnerhagen, Katharina S. .
NEUROLOGY, 2018, 91 (16) :E146-1467
[15]   Baseline NIH Stroke Scale Score predicting outcome in anterior and posterior circulation strokes [J].
Sato, S. ;
Toyoda, K. ;
Uehara, T. ;
Toratani, N. ;
Yokota, C. ;
Moriwaki, H. ;
Naritomi, H. ;
Minematsu, K. .
NEUROLOGY, 2008, 70 (24) :2371-2377
[16]   The prevalence of frailty among acute stroke patients, and evaluation of method of assessment [J].
Taylor-Rowan, Martin ;
Cuthbertson, Gillian ;
Keir, Ruth ;
Shaw, Robert ;
Drozdowska, Bogna ;
Elliott, Emma ;
Stott, David ;
Quinn, Terence J. .
CLINICAL REHABILITATION, 2019, 33 (10) :1688-1696
[17]   INTEROBSERVER AGREEMENT FOR THE ASSESSMENT OF HANDICAP IN STROKE PATIENTS [J].
VANSWIETEN, JC ;
KOUDSTAAL, PJ ;
VISSER, MC ;
SCHOUTEN, HJA ;
VANGIJN, J .
STROKE, 1988, 19 (05) :604-607
[18]   Frailty and the Prediction of Negative Health Outcomes: A Meta-Analysis [J].
Vermeiren, Sofie ;
Vella-Azzopardi, Roberta ;
Beckwee, David ;
Habbig, Ann-Katrin ;
Scafoglieri, Aldo ;
Jansen, Bart ;
Bautmans, Ivan .
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2016, 17 (12) :1163.e1-1163.e17
[19]   Predicting functional outcome and survival after acute ischemic stroke [J].
Weimar, C ;
Ziegler, A ;
König, IR ;
Diener, HC .
JOURNAL OF NEUROLOGY, 2002, 249 (07) :888-895
[20]   Pre-stroke physical activity is associated with fewer post-stroke complications, lower mortality and a better long-term outcome [J].
Wen, C. -P. ;
Liu, C. -H. ;
Jeng, J. -S. ;
Hsu, S. -P. ;
Chen, C. -H. ;
Lien, L. -M. ;
Chen, A. -C. ;
Lee, J. -T. ;
Chen, P. -K. ;
Hsu, C. -S. ;
Chern, C. -M. ;
Chen, C. -C. ;
Hsu, M. -C. ;
Lu, K. ;
Chen, H. -J. ;
Wang, H. -K. ;
Muo, C. -H. ;
Hsu, C. -Y. .
EUROPEAN JOURNAL OF NEUROLOGY, 2017, 24 (12) :1525-1531
123