Localization of calcitonin receptor mRNA in the mouse brain: coexistence with serotonin transporter mRNA

被引：42
作者：
Nakamoto, H [1 ]
Soeda, Y [1 ]
Takami, S [1 ]
Minami, M [1 ]
Satoh, M [1 ]
机构：
[1] Kyoto Univ, Fac Pharmaceut Sci, Dept Mol Pharmacol, Kyoto 6068501, Japan
来源：
MOLECULAR BRAIN RESEARCH | 2000年 / 76卷 / 01期
关键词：
calcitonin receptor; serotonin transporter; in situ hybridization; antinociception; mouse;
D O I：
10.1016/S0169-328X(99)00335-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To elucidate the sites of and mechanisms of analgesic effect of centrally injected calcitonin, we examined expression of calcitonin receptor mRNA in the mouse brain by in situ hybridization techniques. Calcitonin receptor mRNA was expressed in various brain regions, including the preoptic area, dorsomedial hypothalamic nucleus, lateral hypothalamic area, periaqueductal gray, dorsal raphe nucleus, locus coeruleus, lateral parabrachial nucleus, gigantocellular reticular nucleus alpha part, lateral paragigantocellular nucleus, raphe magnus nucleus and solitary tract nucleus, which are known to play important roles in pain modulation. In addition, a double in situ hybridization technique demonstrated the intense expression of calcitonin receptor mRNA on serotonergic neurons in some raphe nuclei and the lateral paragigantocellular nucleus, suggesting the involvement of central serotonergic pathways in analgesic effect of calcitonin. (C) 2000 Elsevier Science B.V. All rights reserved.
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页码：93 / 102
页数：10
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