Molecular study of the sodium-iodide symporter (NIS): A new field in thyroidology

被引：36

作者：

Dohan, O ^{[1
]}

De la Vieja, A ^{[1
]}

Carrasco, N ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2000年 / 11卷 / 03期

关键词：

D O I：

10.1016/S1043-2760(00)00237-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The active transport of iodide into the thyroid is mediated by the Na+-I- symporter (NIS), an intrinsic membrane protein. NIS plays key roles in thyroid pathophysiology as the route by which I- reaches the gland for thyroid hormone biosynthesis, and as a means for diagnostic scintigraphic imaging and for radioiodide therapy in thyroid cancer. The molecular characterization of NIS started with the isolation in 1996 of a cDNA encoding vat NIS, and has subsequently Zed to a virtually new field in thyroidology. The research reviewed in this article clearly has far-reaching implications in the areas of structure/function Of transport proteins, thyroid pathophysiology, hormone action mechanisms, cell differentiation and cancer.

引用

页码：99 / 105

页数：7

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