Molecular study of the sodium-iodide symporter (NIS): A new field in thyroidology

被引：36
|
作者：
Dohan, O [1 ]
De la Vieja, A [1 ]
Carrasco, N [1 ]
机构：
[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2000年 / 11卷 / 03期
关键词：
D O I：
10.1016/S1043-2760(00)00237-X
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The active transport of iodide into the thyroid is mediated by the Na+-I- symporter (NIS), an intrinsic membrane protein. NIS plays key roles in thyroid pathophysiology as the route by which I- reaches the gland for thyroid hormone biosynthesis, and as a means for diagnostic scintigraphic imaging and for radioiodide therapy in thyroid cancer. The molecular characterization of NIS started with the isolation in 1996 of a cDNA encoding vat NIS, and has subsequently Zed to a virtually new field in thyroidology. The research reviewed in this article clearly has far-reaching implications in the areas of structure/function Of transport proteins, thyroid pathophysiology, hormone action mechanisms, cell differentiation and cancer.
引用
收藏
页码：99 / 105
页数：7
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