Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats

被引：55
|
作者：
Shimabukuro, M
Zhou, YT
Lee, Y
Unger, RH
机构：
[1] UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,GIFFORD LABS,DALLAS,TX 75235
[2] DEPT VET AFFAIRS MED CTR,DALLAS,TX 75235
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 237卷 / 02期
关键词：
D O I：
10.1006/bbrc.1997.7140
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Because troglitazone, like leptin, lowers the triglyceride (TG) content of pancreatic islets, we searched for other leptinomimetic actions, Leptin upregulates the expression of uncoupling protein-2 (UCP-2) mRNA in islets of normal rats, but has no effect in islets of obese Zucker Diabetic Fatty (ZDF) rats with mutated leptin receptors. We report here that troglitazone also increases the UCP-2/beta-actin mRNA ratio by 115% in wild type ZDF rats and by 400% in obese ZDF rats. (C) 1997 Academic Press.
引用
收藏
页码：359 / 361
页数：3
相关论文
共 50 条
  • [1] Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves β-cell function
    Wang, MY
    Shimabukuro, M
    Lee, Y
    Trinh, KY
    Chen, JL
    Newgard, CB
    Unger, RH
    DIABETES, 1999, 48 (05) : 1020 - 1025
  • [2] Effect of Exercise on Pancreatic Islets in Zucker Diabetic Fatty Rats
    Rawal, Sonia
    Huang, Han-Hung
    Novikova, Lesya
    Hamedi, Tyler
    Smirnova, Irina V.
    Stehno-Bittel, Lisa
    JOURNAL OF DIABETES & METABOLISM, 2013, 4
  • [3] Progressive histopathological changes in pancreatic islets of Zucker Diabetic Fatty rats
    Janssen, SWJ
    Hermus, ARMM
    Lange, WPH
    Knijnenburg, Q
    van der Laak, JAWM
    Sweep, CGJ
    Martens, GJM
    Verhofstad, AAJ
    EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2001, 109 (05) : 273 - 282
  • [4] Glucose induction of uncoupling protein-2 mRNA expression and effects of leptin in human islets.
    Brown, JEP
    Thomas, S
    Digby, JE
    Dunmore, SJ
    DIABETOLOGIA, 2000, 43 : A121 - A121
  • [5] Induction of uncoupling protein-2 mRNA by triiodothyronine in rat liver
    Bolehovska, Radka
    Pospisilova, Monika
    Rychtrmoc, David
    Hubalkova, Lenka
    Cervinkova, Zuzana
    ACTA VETERINARIA BRNO, 2012, 81 (01) : 75 - 81
  • [6] Troglitazone modulates type 2 renal Na/Pi cotransport protein in Zucker diabetic fatty rats
    Halaihel, N
    Zajicek, H
    Sun, L
    Wilson, P
    Zhou, YT
    Levi, M
    DIABETES, 2000, 49 : A156 - A156
  • [7] Glucose induction of uncoupling protein-2 mRNA expression in human islets is not reversed by subsequent reduction in glucose concentration
    Brown, JEP
    Thomas, S
    Digby, JE
    Dunmore, SJ
    DIABETES, 2001, 50 : A363 - A363
  • [8] Troglitazone alters substrate storage and utilization in Zucker diabetic fatty rats
    Sreenan, S
    Keck, S
    Fuller, T
    Burant, C
    DIABETES, 1998, 47 : A278 - A278
  • [9] Effect of Troglitazone on development of diabetes in Zucker diabetic fatty (ZDF) rats
    Fujiwara, T
    Hagisawa, Y
    Yorikane, E
    Takahashi, S
    Araki, K
    Fukushige, J
    Hosokawa, T
    Horikoshi, H
    DIABETES, 1997, 46 : 291 - 291
  • [10] Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets
    Brown, JEP
    Thomas, S
    Digby, JE
    Dunmore, SJ
    FEBS LETTERS, 2002, 513 (2-3) : 189 - 192
12345