Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation

被引：100

作者：

Akari, H

Arold, S

Fukumori, T

Okazaki, T

Strebel, K

Adachi, A

机构：

[1] Univ Tokushima, Sch Med, Dept Virol, Tokushima 7708503, Japan

[2] NIAID, Mol Microbiol Lab, Bethesda, MD 20892 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 06期

关键词：

D O I：

10.1128/JVI.74.6.2907-2912.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The N-terminal alpha-helix domain of the human immunodeficiency virus type 1 (HIV-1) Nef protein plays important roles in enhancement of viral infectivity, virion incorporation of Nef, and the down-regulation of major histocompatibility complex class I (MHC-I) expression on cell surfaces. In this study, we demonstrated that Met 20 in the alpha-helix domain was indispensable for the ability of Nef to modulate MHC-I expression but not for other events. We also showed that Met 20 was unnecessary for the down-regulation of CD4. These findings indicate that the region governing MHC-I down-regulation is proximate in the alpha-helix domain but is dissociated functionally from that determining enhancement of viral infectivity, virion incorporation of Nef, and CD4 down-regulation.

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页码：2907 / 2912

页数：6

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