Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: Safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedules

被引：16
|
作者：
Pichichero, Michael E. [1 ]
Casey, Janet R. [1 ]
Francis, Anne B. [1 ]
Marsocci, Steven M. [1 ]
Murphy, Marie [1 ]
Hoeger, William [1 ]
Cleary, Carolyn [1 ]
机构：
[1] Univ Rochester, Med Ctr, Elmwood Pediat Grp, Rochester, NY 14642 USA
来源：
CLINICAL PEDIATRICS | 2006年 / 45卷 / 07期
关键词：
pcrtussis; vaccines; acellular pertussis; diphtheria; tetanus; clinical trials;
D O I：
10.1177/0009922806289593
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
A sixth dose of tetanus, diphtheria, acellular pertussis (Tdap) vaccine in adolescents might produce a differing reactogenicity and/or immunogenicity response depending on the composition of the 5 prior doses of DTaP or DT-whole cell pertussis (DTwP) vaccine. Reactions and immune responses following receipt of the Sanofi Pasteur (Adacel) and GlaxoSmithKline (Boostrix) Tdap vaccines were assessed in 229 adolescents. No differences were observed for reactions to either Tdap vaccine regardless of the prior DTaP/DTwP vaccination history. Seroprotective levels and antibody concentrations were comparable regardless of prior DTaP/DTwP vaccine history. A sixth sequential dose of Tdap after 5 doses of DTaP appears safe and immunogenic.
引用
收藏
页码：613 / 620
页数：8
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