Biological Interaction Between Copper(II) Complex and Nucleosides

被引：0
作者：
Guo, Yaping [1 ]
Wang, Xiuju [1 ]
Luo, Leiming [2 ]
Du, Jinge [1 ]
Shang, Xuefang [3 ]
机构：
[1] Xinxiang Med Univ, Sanquan Coll, Dept Chem, Xinxiang 453003, Henan Province, Peoples R China
[2] Xinxiang Med Univ, Affiliated Hosp 3, Dept Pharm, Xinxiang 453003, Henan Province, Peoples R China
[3] Xinxiang Med Univ, Dept Chem, Xinxiang 453003, Henan Province, Peoples R China
来源：
ASIAN JOURNAL OF CHEMISTRY | 2014年 / 26卷 / 14期
基金：
中国国家自然科学基金;
关键词：
Biological interaction; Nucleoside; Copper(II) complex; MOLECULAR RECOGNITION; ATP; BINDING; ANIONS; SENSOR; NUCLEOTIDES; HYDROLYSIS; FLUORIDE; RECEPTOR; SITE;
D O I：
10.14233/ajchem.2014.16964
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A copper-coordinated complex based on 7-membered amide cycle has been designed and synthesized. Its binding properties for various nucleosides, guanosine-5'-diphosphate (GDP), uridine-5'-diphosphate (UDP), inosine-5'-diphosphate (IDP) and guanosine-5'-triphosphate (GTP) has been studied by UV-visible spectra and crystal structure. Results indicated that the compound showed the highest binding ability with guanosine-5'-triphosphate in water solution among the studied nucleosides. The interaction of host-guest derived from hydrogen bonding and pi-pi staking and the host-guest binding ability depended on the chain length of nucleosides. In addition, the compound can be used to label nucleoside.
引用
收藏
页码：4457 / 4461
页数：5
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