Panax red ginseng extract regulates energy expenditures by modulating PKA dependent lipid mobilization in adipose tissue

被引：14

作者：

Cho, Hae-Mi ^{[1
]}

Kang, Young-Ho ^{[1
]}

Yoo, Hanju ^{[1
]}

Yoon, Seung-Yong ^{[2
]}

Kang, Sang-Wook ^{[1
,2
]}

Chang, Eun-Ju ^{[1
,2
]}

Song, Youngsup ^{[1
,2
]}

机构：

[1] Univ Ulsan, Coll Med, Dept Biomed Sci, Cell Dysfunct Res Ctr, Seoul 138736, South Korea

[2] Univ Ulsan, Coll Med, Dept Anat & Cell Biol, Seoul 138736, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2014年 / 447卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Panax ginseng; Energy expenditures; Protein Kinase A; Obesity; Adipose tissue; ACTIVATED PROTEIN-KINASE; HEPG2; CELLS; RATS; RECEPTOR; AMPK; FAT; PATHWAY; SAPONIN; OBESITY; MICE;

D O I：

10.1016/j.bbrc.2014.04.056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulation of balance between lipid accumulation and energy consumption is a critical step for the maintenance of energy homeostasis. Here, we show that Panax red ginseng extract treatments increased energy expenditures and prevented mice from diet induced obesity. Panax red ginseng extracts strongly activated Hormone Specific Lipase (HSL) via Protein Kinase A (PKA). Since activation of HSL induces lipolysis in WAT and fatty acid oxidation in brown adipose tissue (BAT), these results suggest that Panax red ginseng extracts reduce HFD induced obesity by regulating lipid mobilization. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：644 / 648

页数：5

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