Relationship of Hemoglobin A1c with β Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients

被引:28
作者
Hou, Xinguo [1 ]
Liu, Jinbo [1 ]
Song, Jun [1 ]
Wang, Chuan [1 ]
Liang, Kai [1 ]
Sun, Yu [1 ]
Ma, Zeqiang [2 ]
Yang, Weifang [3 ]
Li, Chengqiao [4 ]
Zhang, Xiuping [5 ]
Lin, Peng [1 ]
Gong, Lei [1 ]
Wang, Meijian [1 ]
Liu, Fuqiang [1 ]
Li, Wenjuan [1 ]
Yan, Fei [1 ]
Qin, Jun [1 ]
Wang, Lingshu [1 ]
Liu, Jidong [1 ]
Zhao, Ruxing [1 ]
Chen, Shihong [6 ]
Chen, Li [1 ]
机构
[1] Shandong Univ, Dept Endocrinol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China
[2] China Natl Heavy Duty Truck Grp Corp Hosp, Jinan 250116, Shandong, Peoples R China
[3] Lukang Hosp Jining, Jining 272141, Shandong, Peoples R China
[4] Second Peoples Hosp Jining, Dept Endocrinol, Jining 272049, Shandong, Peoples R China
[5] Shantui Community Hlth Ctr, Jining 272000, Shandong, Peoples R China
[6] Shandong Univ, Dept Endocrinol, Hosp 2, Jinan 250012, Shandong, Peoples R China
基金
中国国家自然科学基金;
关键词
RISK-EVALUATION; PRESERVATION; PATHOGENESIS; INDIVIDUALS; DYSFUNCTION; GLUCOSE; CANCERS;
D O I
10.1155/2016/8797316
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To investigate changes in the glycated hemoglobin A1c (A1c) level and those in beta cell function and insulin resistance in newly diagnosed and drug naive type 2 diabetes patients and to evaluate the relationship between them. Design and Methods. A total of 818 newly diagnosed diabetic individuals who were >= 40 years of age were recruited. The subjects were grouped by A1c values (< 6.5%, 6.5-7%, 7-8%, 8-9%, and >= 9%). The homeostasis model assessment (HOMA) was used to evaluate pancreatic beta cell function (HOMA-beta) and insulin resistance (HOMA-IR). ANOVA, t-tests, and binary logistic regression analysis were used for data analysis. Results. Compared with subjects with A1c values < 6.5%, individuals with an A1c of 6.5-7% exhibited an increased HOMA-beta index. However, the HOMA-beta index was significantly decreased at A1c values >= 7% and further decreased by 9.3% and by 23.7%, respectively, at A1c values of 7-8% and 8-9%. As A1c increased to >= 9%, a 62% reduction in beta cell function was observed, independently of age, gender, body mass index (BMI), blood pressure (BP), blood lipids, and hepatic enzyme levels. Meanwhile, insulin resistance was significantly increased with an increase in A1c values. Conclusions. Elevated A1c values (>= 7%) were associated with substantial reductions in beta cell function.
引用
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页数:6
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