New celiac disease biomarkers

被引：2
作者：
Rodriguez-Martin, Laura [1 ]
Vaquero, Luis [1 ]
Vivas, Santiago [1 ]
机构：
[1] Univ Leon, Digest Dis Unit, Complejo Asistencial Univ Leon, Inst Biomed,Biomed Sci Dept, Leon, Spain
来源：
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS | 2020年 / 112卷 / 10期
关键词：
Celiac disease; Biomarker; Enteropathy; Serology; SERUM I-FABP; GLUTEN-FREE DIET; ENTEROCYTE DAMAGE; MARKER;
D O I：
10.17235/reed.2020.7217/2020
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Advances in the knowledge regarding celiac disease have enabled the development of diagnostic markers, such as anti-tissue transglutaminase and anti-deaminated gliadin antibodies. The wide availability of these antibodies, genetic studies of HLA-DQ and duodenal biopsies constitute the pillars necessary for a definitive diagnosis. However, difficulties sometimes arise in both the diagnosis and follow-up of celiac patients, which cannot be resolved using these tools. This article reviews the scientific evidence and possible clinical utility of different biomarkers. This review is structured according to biomarkers that have been evaluated pathophysiologically in relation to intestinal damage or immune response and their potential clinical utility in the diagnosis and follow-up of celiac disease patients.
引用
收藏
页码：792 / 796
页数：5
相关论文
共 25 条
[1]   Serum I-FABP as marker for enterocyte damage in coeliac disease and its relation to villous atrophy and circulating autoantibodies [J].
Adriaanse, M. P. M. ;
Tack, G. J. ;
Passos, V. Lima ;
Damoiseaux, J. G. M. C. ;
Schreurs, M. W. J. ;
van Wijck, K. ;
Riedl, R. G. ;
Masclee, A. A. M. ;
Buurman, W. A. ;
Mulder, C. J. J. ;
Vreugdenhil, A. C. E. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2013, 37 (04) :482-490
[2]   Serum Markers in the Clinical Management of Celiac Disease [J].
Adriaanse, Marlou ;
Leffler, Daniel A. .
DIGESTIVE DISEASES, 2015, 33 (02) :236-243
[3]   Serum I-FABP Detects Gluten Responsiveness in Adult Celiac Disease Patients on a Short-Term Gluten Challenge [J].
Adriaanse, Marlou P. M. ;
Leffler, Daniel A. ;
Kelly, Ciaran P. ;
Schuppan, Detlef ;
Najarian, Robert M. ;
Goldsmith, Jeffrey D. ;
Buurman, Wim A. ;
Vreugdenhil, Anita C. E. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2016, 111 (07) :1014-1022
[4]   Duodenal lymphogram as a complementary tool in the diagnosis of celiac disease in adults [J].
Burgueno, Beatriz ;
Escudero-Hernandez, Celia ;
de Pedro, Rodrigo ;
Montalvillo, Enrique ;
Bernardo, David ;
Garcia Lagarto, Elena ;
Garrote Adrados, Jose Antonio ;
Arranz Sanz, Eduardo ;
Fernandez-Salazar, Luis .
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS, 2020, 112 (06) :434-439
[5]   Synthetic Neoepitopes of the Transglutaminase-Deamidated Gliadin Complex as Biomarkers for Diagnosing and Monitoring Celiac Disease [J].
Choung, Rok Seon ;
Rostamkolaei, Shahryar Khaleghi ;
Ju, Josephine M. ;
Marietta, Eric, V ;
Van Dyke, Carol T. ;
Rajasekaran, J. J. ;
Jayaraman, Vasanth ;
Wang, Tianhao ;
Bei, Kang ;
Rajasekaran, Karenah E. ;
Krishna, Karthik ;
Krishnamurthy, Hari Krishnan ;
Murray, Joseph A. .
GASTROENTEROLOGY, 2019, 156 (03) :582-+
[6]   Fecal Gluten Peptides Reveal Limitations of Serological Tests and Food Questionnaires for Monitoring Gluten-Free Diet in Celiac Disease Patients [J].
Comino, Isabel ;
Fernandez-Banares, Fernando ;
Esteve, Maria ;
Ortigosa, Luis ;
Castillejo, Gemma ;
Fambuena, Blanca ;
Ribes-Koninckx, Carmen ;
Sierra, Carlos ;
Rodriguez-Herrera, Alfonso ;
Carlos Salazar, Jose ;
Caunedo, Angel ;
Marugan-Miguelsanz, J. M. ;
Antonio Garrote, Jose ;
Vivas, Santiago ;
lo lacono, Oreste ;
Nunez, Alejandro ;
Vaquero, Luis ;
Maria Vegas, Ana ;
Crespo, Laura ;
Fernandez-Salazar, Luis ;
Arranz, Eduardo ;
Alejandra Jimenez-Garcia, Victoria ;
Antonio Montes-Cano, Marco ;
Espin, Beatriz ;
Galera, Ana ;
Valverde, Justo ;
Jose Giron, Francisco ;
Bolonio, Miguel ;
Millan, Antonio ;
Martinez Cerezo, Francesc ;
Guajardo, Cesar ;
Ramon Alberto, Jose ;
Rosinach, Merce ;
Segura, Veronica ;
Leon, Francisco ;
Marinich, Jorge ;
Munoz-Suano, Alba ;
Romero-Gomez, Manuel ;
Cebolla, Angel ;
Sousa, Carolina .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2016, 111 (10) :1456-1465
[7]   Monitoring of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces [J].
Comino, Isabel ;
Real, Ana ;
Vivas, Santiago ;
Angel Siglez, Miguel ;
Caminero, Alberto ;
Nistal, Esther ;
Casqueiro, Javier ;
Rodriguez-Herrera, Alfonso ;
Cebolla, Angel ;
Sousa, Carolina .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2012, 95 (03) :670-677
[8]   Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing [J].
de Lourdes Moreno, Maria ;
Cebolla, Angel ;
Munoz-Suano, Alba ;
Carrillo-Carrion, Carolina ;
Comino, Isabel ;
Pizarro, Angeles ;
Leon, Francisco ;
Rodriguez-Herrera, Alfonso ;
Sousa, Carolina .
GUT, 2017, 66 (02) :250-257
[9]   Citrulline as a marker of intestinal function and absorption in clinical settings: A systematic review and meta-analysis [J].
Fragkos, Konstantinos C. ;
Forbes, Alastair .
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL, 2018, 6 (02) :181-191
[10]   Potential role of the IL-33/ST2 axis in celiac disease [J].
Lopez-Casado, M. A. ;
Lorite, P. ;
Palomeque, T. ;
Torres, M., I .
CELLULAR & MOLECULAR IMMUNOLOGY, 2017, 14 (03) :285-292
123