Calculating the number needed to treat for trials where the outcome is time to an event

被引：550

作者：

Altman, DG ^{[1
]}

Andersen, PK

机构：

[1] Inst Hlth Sci, Ctr Stat Med, Imperial Canc Res Grp, Med Stat Grp, Oxford OX3 7LF, England

[2] Univ Copenhagen, Dept Biostat, DK-2200 Copenhagen N, Denmark

来源：

BRITISH MEDICAL JOURNAL | 1999年 / 319卷 / 7223期

关键词：

D O I：

10.1136/bmj.319.7223.1492

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The number needed to treat is the number of patients who need to be treated to prevent one additional adverse outcome. This number (with confidence interval) is a clinically useful way to report the results of controlled trials. For any trial which has reported a binary outcome, the number needed to treat can be obtained as the reciprocal of the absolute difference in proportions of patients with the outcome of interest. In studies where the outcome of interest is the time to an event, calculations can be extended to show the number needed to treat at any time after the start of treatment.

引用

页码：1492 / 1495

页数：4

共 11 条

[1] REVIEW OF SURVIVAL ANALYSES PUBLISHED IN CANCER JOURNALS [J].

ALTMAN, DG ;

DESTAVOLA, BL ;

LOVE, SB ;

STEPNIEWSKA, KA .

BRITISH JOURNAL OF CANCER, 1995, 72 (02) :511-518

[2] Confidence intervals for the number needed to treat [J].

Altman, DG .

BRITISH MEDICAL JOURNAL, 1998, 317 (7168) :1309-1312

[3] THE NUMBER NEEDED TO TREAT - A CLINICALLY USEFUL MEASURE OF TREATMENT EFFECT [J].

COOK, RJ ;

SACKETT, DL .

BRITISH MEDICAL JOURNAL, 1995, 310 (6977) :452-454

[4]

LAD T, 1988, J CLIN ONCOL, V6, P9

[5] Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus [J].

Malmberg, K .

BRITISH MEDICAL JOURNAL, 1997, 314 (7093) :1512-1515

[6] Using numerical results from systematic reviews in clinical practice [J].

McQuay, HJ ;

Moore .

ANNALS OF INTERNAL MEDICINE, 1997, 126 (09) :712-720

[7] Secondary prevention for ischemic heart disease - Relative numbers needed to treat with different therapies [J].

Miller, DB .

ARCHIVES OF INTERNAL MEDICINE, 1997, 157 (18) :2045-2052

[8]

Oates GD, 1996, LANCET, V348, P1605

[9]

Piantadosi S, 1997, CLIN TRIALS METHODOL

[10]

SACKETT DL, 1997, EVIDENCE BASED MED P, P136

← 1 2 →