How does a protein search for the specific site on DNA: The role of disorder

被引：31
作者：
Hu, Tao [1 ]
Shklovskii, B. I. [1 ]
机构：
[1] Univ Minnesota, Dept Phys, Minneapolis, MN 55455 USA
来源：
PHYSICAL REVIEW E | 2006年 / 74卷 / 02期
关键词：
REPRESSOR-OPERATOR INTERACTION; DIFFUSION-DRIVEN MECHANISMS; NUCLEIC-ACIDS; TRANSLOCATION;
D O I：
10.1103/PhysRevE.74.021903
中图分类号：
O35 [流体力学]; O53 [等离子体物理学];
学科分类号：
070204 ; 080103 ; 080704 ;
摘要：
Proteins can locate their specific targets on DNA up to two orders of magnitude faster than the Smoluchowski three-dimensional diffusion rate. This happens due to nonspecific adsorption of proteins to DNA and subsequent one-dimensional sliding along DNA. We call such a one-dimensional route towards the target an "antenna." We studied the role of the dispersion of nonspecific binding energies within the antenna due to a quasirandom sequence of natural DNA. A random energy profile for sliding proteins slows the searching rate for the target. We show that this slowdown is different for macroscopic and mesoscopic antennas.
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页数：4
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