Description and Nomenclature of Neisseria meningitidis Capsule Locus

被引:239
作者
Harrison, Odile B. [1 ]
Claus, Heike [3 ]
Jiang, Ying [4 ]
Bennett, Julia S. [2 ]
Bratcher, Holly B. [2 ]
Jolley, Keith A. [2 ]
Corton, Craig [4 ]
Care, Rory [5 ]
Poolman, Jan T. [6 ]
Zollinger, Wendell D. [7 ]
Frasch, Carl E. [8 ]
Stephens, David S. [9 ]
Feavers, Ian [5 ]
Frosch, Matthias [3 ]
Parkhill, Julian [4 ]
Vogel, Ulrich [3 ]
Quail, Michael A. [4 ]
Bentley, Stephen D. [4 ]
Maiden, Martin C. J. [2 ]
机构
[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England
[2] Univ Oxford, Oxford OX1 3PS, England
[3] Univ Wurzburg, D-97070 Wurzburg, Germany
[4] Sanger Inst, Cambridge, England
[5] Natl Inst Biol Stand & Controls, Potters Bar, Herts, England
[6] Crucell, Leiden, Netherlands
[7] Walter Reed Army Inst Res, Silver Spring, MD USA
[8] Frasch Biol Consulting, Martinsburg, WV USA
[9] Emory Univ, Atlanta, GA 30322 USA
基金
英国惠康基金;
关键词
MENINGOCOCCAL POLYSACCHARIDES; STRUCTURAL DETERMINATION; CHEMICAL-PROPERTIES; SEROGROUP-Y; ANTIGEN; BIOSYNTHESIS; ELUCIDATION; EXPRESSION; GENETICS; SEQUENCE;
D O I
10.3201/eid1904.111799
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity. Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps. The use of multiple names for some of the genes involved in capsule synthesis, combined with the need for rapid diagnosis of serogroups commonly associated with invasive meningococcal disease, prompted a requirement for a consistent approach to the nomenclature of capsule genes. In this report, a comprehensive description of all N. meningitidis serogroups is provided, along with a proposed nomenclature, which was presented at the 2012 XVIIIth International Pathogenic Neisseria Conference.
引用
收藏
页码:566 / 573
页数:8
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