bNAber: database of broadly neutralizing HIV antibodies

被引：58

作者：

Eroshkin, Alexey M. ^{[1
,2
]}

LeBlanc, Andrew ^{[1
,2
]}

Weekes, Dana ^{[1
,2
]}

Post, Kai ^{[1
,2
]}

Li, Zhanwen ^{[2
]}

Rajput, Akhil ^{[1
,2
]}

Butera, Sal T. ^{[1
,3
]}

Burton, Dennis R. ^{[1
,3
,4
]}

Godzik, Adam ^{[1
,2
,5
]}

机构：

[1] Scripps Res Inst, Ctr HIV AIDS Vaccine Immunol & Immunogen Discover, La Jolla, CA 92037 USA

[2] Sanford Burnham Med Res Inst, Bioinformat & Syst Biol Program, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA

[4] Ragon Inst MGH & Harvard, Cambridge, MA 02139 USA

[5] Univ Calif San Diego, Ctr Res Biol Syst, La Jolla, CA 92093 USA

来源：

NUCLEIC ACIDS RESEARCH | 2014年 / 42卷 / D1期

基金：

美国国家卫生研究院;

关键词：

MONOCLONAL-ANTIBODIES; SEQUENCE; DESIGN;

D O I：

10.1093/nar/gkt1083

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of broadly neutralizing antibodies (bNAbs) has provided an enormous impetus to the HIV vaccine research and to entire immunology. The bNAber database at http://bNAber.org provides open, user-friendly access to detailed data on the rapidly growing list of HIV bNAbs, including neutralization profiles, sequences and three-dimensional structures (when available). It also provides an extensive list of visualization and analysis tools, such as heatmaps to analyse neutralization data as well as structure and sequence viewers to correlate bNAbs properties with structural and sequence features of individual antibodies. The goal of the bNAber database is to enable researchers in this field to easily compare and analyse available information on bNAbs thereby supporting efforts to design an effective vaccine for HIV/AIDS. The bNAber database not only provides easy access to data that currently is scattered in the Supplementary Materials sections of individual papers, but also contributes to the development of general standards of data that have to be presented with the discovery of new bNAbs and a universal mechanism of how such data can be shared.

引用

页码：D1133 / D1139

页数：7

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