Genome instability: Linking ageing and brain degeneration

被引：14

作者：

Barzilai, Ari ^{[1
]}

Schumacher, Bjoern ^{[2
]}

Shiloh, Yosef ^{[3
,4
,5
]}

机构：

[1] Sagol Sch Neurosci, George S Wise Fac Life Sci, Dept Neurobiol, Tel Aviv, Israel

[2] Tel Aviv Univ, Sackler Sch Med, Dept Human Mol Genet & Biochem, IL-69978 Tel Aviv, Israel

[3] Inst Genome Stabil Ageing & Dis, Cologne, Germany

[4] Univ Cologne, Fac Med, Cologne, Germany

[5] Univ Cologne, CECAD Res Center, Cologne, Germany

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2017年 / 161卷

基金：

欧洲研究理事会; 以色列科学基金会;

关键词：

STRAND BREAK REPAIR; DNA-DAMAGE RESPONSE; NUCLEOTIDE EXCISION-REPAIR; UNFOLDED PROTEIN RESPONSE; ATM-DEFICIENT MICE; ATAXIA-TELANGIECTASIA; ALZHEIMERS-DISEASE; SENESCENT CELLS; MOUSE MODEL; MOLECULAR-MECHANISMS;

D O I：

10.1016/j.mad.2016.03.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ageing is a multifactorial process affected by cumulative physiological changes resulting from stochastic processes combined with genetic factors, which together alter metabolic homeostasis. Genetic variation in maintenance of genome stability is emerging as an important determinant of ageing pace. Genome instability is also closely associated with a broad spectrum of conditions involving brain degeneration. Similarities and differences can be found between ageing-associated decline of brain functionality and the detrimental effect of genome instability on brain functionality and development. This review discusses these similarities and differences and highlights cell classes whose role in these processes might have been underestimated glia and microglia. (C) 2016 Published by Elsevier Ireland Ltd.

引用

页码：4 / 18

页数：15

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