Identification of Putative Target Genes of the Transcription Factor RUNX2

被引：21

作者：

Kuhlwilm, Martin ^{[1
]}

Davierwala, Armaity ^{[1
]}

Paeaebo, Svante ^{[1
]}

机构：

[1] Max Planck Inst Evolutionary Anthropol, Leipzig, Germany

来源：

PLOS ONE | 2013年 / 8卷 / 12期

关键词：

NF-KAPPA-B; OSTEOBLAST DIFFERENTIATION; CBFA1; EXPRESSION; DEPHOSPHORYLATION; APOPTOSIS; SEQUENCE; PACKAGE; SUTURE; ARREST;

D O I：

10.1371/journal.pone.0083218

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Comparisons of the genomes of Neandertals and Denisovans with present-day human genomes have suggested that the gene RUNX2, which encodes a transcription factor, may have been positively selected during early human evolution. Here, we overexpress RUNX2 in ten human cell lines and identify genes that are directly or indirectly affected by RUNX2 expression. We find a number of genes not previously known to be affected by RUNX2 expression, in particular BIRC3, genes encoded on the mitochondrial genome, and several genes involved in bone and tooth formation. These genes are likely to provide inroads into pathways affected by RUNX2 and potentially by the evolutionary changes that affected RUNX2 in modern humans.

引用

页数：9

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