Functional Haplotypes That Produce Normal Ficolin-2 Levels Protect against Clinical Leprosy

被引：50

作者：

de Messias-Reason, Iara ^{[1
,2
,3
]}

Kremsner, Peter G. ^{[1
]}

Kun, Juergen F. J. ^{[1
]}

机构：

[1] Univ Tubingen, Dept Parasitol, Inst Trop Med, D-72074 Tubingen, Germany

[2] Univ Fed Parana, Immunopathol Lab, BR-80060000 Curitiba, Parana, Brazil

[3] Univ Fed Parana, Dept Med Pathol, BR-80060000 Curitiba, Parana, Brazil

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 199卷 / 06期

关键词：

FCN2; GENE; POLYMORPHISMS; DISEASE; SUSCEPTIBILITY;

D O I：

10.1086/597070

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule. A total of 158 patients with leprosy and 210 healthy control subjects from Brazil were investigated. Polymorphisms in the promoter and exon 8 of FCN2 were assessed by DNA sequencing. The distribution of functional FCN2 haplotypes among patients was significant different from that among the control subjects (P = .004). These results unveil an immunogenetic role for ficolin-2 in the host response against M. leprae.

引用

页码：801 / 804

页数：4

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