Using NMR for ligand discovery and optimization

被引：39

作者：

Villar, HO ^{[1
]}

Yan, JL ^{[1
]}

Hansen, MR ^{[1
]}

机构：

[1] Triad Therapeut, San Diego, CA 92121 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2004年 / 8卷 / 04期

关键词：

D O I：

10.1016/j.cbpa.2004.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several recent technology-driven advances in the area of NMR have rekindled an interest in the application of the technology to problems in drug discovery and development. A unique aspect of NMR is that it has applicability in broadly different areas of the drug discovery and optimization processes NMR techniques for screening aimed at the discovery of novel ligands or low molecular weight structures for fragment based build up procedures are being applied commonly in the industry. Application of NMR in structure-guided drug design and metabonomics are also becoming routine. We present an overview of some of the most recent NMR developments in these areas.

引用

页码：387 / 391

页数：5

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