Synthesis and analgesic activity of some 2-[{4-(alkyl thio-ureido)phenyl}sulphonamido]-6-substituted benzothiazoles

被引：0
|
作者：
Siddiqui, N [1 ]
Alam, M [1 ]
Siddiqui, AA [1 ]
机构：
[1] Jamia Hamdard, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2004年 / 16卷 / 02期
关键词：
benzothiazole; alkylisothiocyanate; analgesic;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Series of sulphonamide derivatives (5a-i) were prepared by condensation of 2-(4-aminophenyl sulphonamido)-6-substituted benzothiazoles with alkyl isothiocyanates. The compound 5g with methoxy substitution showed maximum analgesic activity in the series. Highly significant results were also observed with compound 5b, 5f and 5h whereas other compounds of the series showed a decrease in analgesic activity.
引用
收藏
页码：1005 / 1008
页数：4
相关论文
共 50 条
  • [1] Synthesis and antibacterial activity of some new 2-(substituted phenyl sulfonamido)-6-substituted benzothiazoles
    Bhusare, SR
    Pawar, RP
    Vibhute, YB
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2001, 11 (01) : 79 - 80
  • [2] Synthesis and antitubercular activity of some substituted 2-(4-aminophenyl sulphonamido) benzothiazoles
    Bhusari, KP
    Khedekar, PB
    Umathe, SN
    Bahekar, RH
    Rao, ARR
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2000, 9 (03) : 213 - 216
  • [3] Synthesis and antibacterial activity of some 2-[(4′-halophenyl) thioureido]-6-substituted benzothiazoles
    Javed, SA
    Siddliqui, N
    Drabu, S
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2004, 13 (03) : 287 - 288
  • [4] SYNTHESIS OF 2-(4'-ALKOXYPHENYL)-6-SUBSTITUTED BENZOTHIAZOLES AND THEIR LIQUID CRYSTAL CHARACTERS
    Zhong E LU Yi Liang MA Song Shan GUO Ke Qian CHEN Department of Chemistry
    ChineseChemicalLetters, 1991, (09) : 727 - 728
  • [5] Synthesis and In vitro Antimicrobial Activity of Novel 2-(4-(Substituted-carboxamido)benzyl/phenyl)benzothiazoles
    Yilmaz, Serap
    Yalcin, Ismail
    Kaynak-Onurdag, Fatma
    Ozgen, Selda
    Yildiz, Ilkay
    Aki, Esin
    CROATICA CHEMICA ACTA, 2013, 86 (02) : 223 - 231
  • [6] Synthesis and Characterisation of 2-(4-(Aryl)phenyl)benzothiazoles
    Lee, Jae Hyeok
    Choi, Yu Bin
    Kim, Dong-Eun
    Shin, Hoon-Kyu
    Lee, Burm-Jong
    CHEMICAL PHYSICS LETTERS, 2022, 789
  • [7] Syntheses and Mesomorphic Properties of 2-(4'-Alkoxyphenyl)-6-Substituted Benzothiazoles
    LU Zhong-e
    Chemical Research in Chinese Universities, 1992, (02) : 164 - 168
  • [8] PREPARATION AND ACTIVITY OF 4'-THIO DERIVATIVES OF SOME 6-SUBSTITUTED PURINE NUCLEOSIDES
    BOBEK, M
    WHISTLER, RL
    BLOCK, A
    JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (03) : 411 - &
  • [9] Scalable synthesis and antibacterial evaluation of 2-(3-(N-(substituted phenyl)sulfamoyl)ureido)benzothiazoles
    Cheraiet, Zinelaabidine
    Meliani, Saida
    Nessaib, Mounir
    Hessainia, Sihem
    Boukhari, Abbas
    Djahoudi, Abdelghani
    Regainia, Zine
    ARCHIV DER PHARMAZIE, 2019, 352 (08)
  • [10] SYNTHESIS OF 2-(SUBSTITUTED ANILINO) 4-(SUBSTITUTED PHENYL)THIAZOLES
    THAKAR, KA
    GOSWAMI, DD
    CHOUDHARI, SR
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1978, 67 (04) : 587 - 589
12345