Distinct effects of MK-801 and (+/-)-2-amino-5-phosphonopentanoic acid on N-methyl-D-aspartate-induced rise of brain temperature in rats

被引:5
作者
Hara, S
Mukai, T
Kuriiwa, F
Iwata, N
Yanase, T
Kano, S
Endo, T
机构
[1] Department of Forensic Medicine, Tokyo Medical College, Tokyo 160, 6-1-1 Shinjuku, Shinjuku-ku
关键词
N-methyl-D-aspartate; MK-801; (+/-)-2-amino-5-phosphonopentanoic acid; brain temperature;
D O I
10.1016/S0024-3205(97)00867-9
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Intracerebroventricular (i.c.v.) administration of N-methyl-D-aspartate (NMDA) caused a biphasic rise of brain temperature, namely, a rapid, early rise and a larger, late rise, in urethane-anesthetized rats. I.c.v. pretreatment with a noncompetitive NMDA receptor antagonist, MK-801, attenuated the late rise of the brain temperature, but had no effect on the early rise, whereas i.c.v. pretreatment with a competitive NMDA receptor antagonist, (+/-)-2-amino-5-phosphonopentanoic acid (AP-5), attenuated both rises. AP-5 per se caused a rise in brain temperature without any rise of rectal temperature, whereas MK-801 per se caused no significant change of the brain or rectal temperature. This rise by AP-5 was suppressed by MK-801, suggesting an agonistic effect of AP-5 on NMDA receptors in rat brain in vivo. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:PL289 / PL294
页数:6
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