Epigenetic Control of Immunity

被引：86
作者：
Busslinger, Meinrad [1 ]
Tarakhovsky, Alexander [2 ]
机构：
[1] Vienna Bioctr, Res Inst Mol Pathol, A-1030 Vienna, Austria
[2] Rockefeller Univ, Lab Lymphocyte Signaling, New York, NY 10021 USA
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2014年 / 6卷 / 06期
关键词：
HEAVY-CHAIN LOCUS; HISTONE-MODIFYING ENZYMES; B-CELL DEVELOPMENT; IGH LOCUS; GENE-EXPRESSION; CHROMATIN ARCHITECTURE; LINEAGE SPECIFICATION; IMMUNOGLOBULIN LOCI; REGULATORY ELEMENTS; SOMATIC MUTATIONS;
D O I：
10.1101/cshperspect.a019307
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Immunity relies on the heterogeneity of immune cells and their ability to respond to pathogen challenges. In the adaptive immune system, lymphocytes display a highly diverse antigen receptor repertoire that matches the vast diversity of pathogens. In the innate immune system, the cell's heterogeneity and phenotypic plasticity enable flexible responses to changes in tissue homeostasis caused by infection or damage. The immune responses are calibrated by the graded activity of immune cells that can vary from yeast-like proliferation to lifetime dormancy. This article describes key epigenetic processes that contribute to the function of immune cells during health and disease.
引用
收藏
页数：26
相关论文
共 140 条
[1]   Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans [J].
Adelman, Karen ;
Lis, John T. .
NATURE REVIEWS GENETICS, 2012, 13 (10) :720-731
[2]  
Bacher CP, 2006, NAT CELL BIOL, V8, P293, DOI 10.1038/ncb1365
[3]   Multiple Sequence-Specific Factors Generate the Nucleosome-Depleted Region on CLN2 Promoter [J].
Bai, Lu ;
Ondracka, Andre ;
Cross, Frederick R. .
MOLECULAR CELL, 2011, 42 (04) :465-476
[4]   Gene regulation by nucleosome positioning [J].
Bai, Lu ;
Morozov, Alexandre V. .
TRENDS IN GENETICS, 2010, 26 (11) :476-483
[5]   Cellular Decision Making and Biological Noise: From Microbes to Mammals [J].
Balazsi, Gabor ;
van Oudenaarden, Alexander ;
Collins, James J. .
CELL, 2011, 144 (06) :910-925
[6]   The mechanism and regulation of chromosomal V(D)J recombination [J].
Bassing, CH ;
Swat, W ;
Alt, FW .
CELL, 2002, 109 :S45-S55
[7]   Acetylation inactivates the transcriptional repressor BCL6 [J].
Bereshchenko, OR ;
Gu, W ;
Dalla-Favera, R .
NATURE GENETICS, 2002, 32 (04) :606-613
[8]   Transcript Dynamics of Proinflammatory Genes Revealed by Sequence Analysis of Subcellular RNA Fractions [J].
Bhatt, Dev M. ;
Pandya-Jones, Amy ;
Tong, Ann-Jay ;
Barozzi, Iros ;
Lissner, Michelle M. ;
Natoli, Gioacchino ;
Black, Douglas L. ;
Smale, Stephen T. .
CELL, 2012, 150 (02) :279-290
[9]   Noise in eukaryotic gene expression [J].
Blake, WJ ;
Kærn, M ;
Cantor, CR ;
Collins, JJ .
NATURE, 2003, 422 (6932) :633-637
[10]   Antisense intergenic transcription in V(D)J recombination [J].
Bolland, DJ ;
Wood, AL ;
Johnston, CM ;
Bunting, SF ;
Morgan, G ;
Chakalova, L ;
Fraser, PJ ;
Corcoran, AE .
NATURE IMMUNOLOGY, 2004, 5 (06) :630-637
12345678910