Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis

被引：57

作者：

Kim, Kiyoon ^{[1
]}

Yu, Miran ^{[1
]}

Han, Seulhee ^{[1
]}

Oh, Inkyung ^{[1
]}

Choi, Young-Jun ^{[2
]}

Kim, Sungsoo ^{[1
]}

Yoon, Kyungsik ^{[1
]}

Jung, Minhyung ^{[2
]}

Choe, Wonchae ^{[1
]}

机构：

[1] Kyung Hee Univ, Sch Med, Dept Biochem & Mol Biol, Inst Biomed Sci,Med Sci & Engn Res Ctr Bireact Re, Seoul 130701, South Korea

[2] Kyung Hee Univ, Sch Med, Dept Obstet & Gynecol, Seoul 130701, South Korea

来源：

ONCOLOGY REPORTS | 2009年 / 21卷 / 06期

关键词：

peroxireoxin; reactive oxidative species; cervical cancer; CELL LUNG-CANCER; I EXPRESSION; OVEREXPRESSION; THIOREDOXIN; PROTEIN; MARKER; TUMORS; GENE;

D O I：

10.3892/or_00000366

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite considerable progress in understanding the function of peroxiredoxin (Prx) in cancer, its expression patterns have not been extensively studied in response to cervical carcinogenesis. We evaluated the expression of Prx isoforms in normal tissue, cervical intraepithelial neoplasia (CIN1, CIN2, and CIN3), and cervical cancer. We found strong pattern of increased Prx II and III immunostaining with increasing severity of the lesion. No difference in staining intensity by grade of lesion was observed for Prx I, and IV. Therefore, we Conclude that Prx II and III are upregulated in response to the development of cervical cancer.

引用

页码：1391 / 1396

页数：6

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