Possible Mechanism of Hematocrit Elevation by Sodium Glucose Cotransporter 2 Inhibitors and Associated Beneficial Renal and Cardiovascular Effects

被引：216
作者：
Sano, Motoaki [1 ]
Goto, Shinichi [1 ]
机构：
[1] Keio Univ, Sch Med, Dept Cardiol, Tokyo, Japan
来源：
CIRCULATION | 2019年 / 139卷 / 17期
关键词：
cell transdifferentiation; heart failure; hematocrit; hypoxia; sodium-potassium pump; sympathetic nervous system;
D O I：
10.1161/CIRCULATIONAHA.118.038881
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
[No abstract available]
引用
收藏
页码：1985 / 1987
页数：3
相关论文
共 5 条
[1]   Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes [J].
Heerspink, H. J. Lambers ;
de Zeeuw, D. ;
Wie, L. ;
Leslie, B. ;
List, J. .
DIABETES OBESITY & METABOLISM, 2013, 15 (09) :853-862
[2]   Acute SGLT inhibition normalizes O2 tension in the renal cortex but causes hypoxia in the renal medulla in anaesthetized control and diabetic rats [J].
O'Neill, Julie ;
Fasching, Angelica ;
Pihl, Liselotte ;
Patinha, Daniela ;
Franzen, Stephanie ;
Palm, Fredrik .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2015, 309 (03) :F227-F234
[3]   Changes in heart rate in patients with type2 diabetes mellitus after treatment with luseogliflozin: Subanalysis of placebo-controlled, double-blind clinical trials [J].
Sano, Motoaki ;
Chen, Shi ;
Imazeki, Hisae ;
Ochiai, Hidekazu ;
Seino, Yutaka .
JOURNAL OF DIABETES INVESTIGATION, 2018, 9 (03) :638-641
[4]   Inappropriately low erythropoietin response for the degree of anemia in patients with noninsulin-dependent diabetes mellitus [J].
Symeonidis, A ;
Kouraklis-Symeonidis, A ;
Psiroyiannis, A ;
Leotsinidis, M ;
Kyriazopoulou, V ;
Vassilakos, P ;
Vagenakis, A ;
Zoumbos, N .
ANNALS OF HEMATOLOGY, 2006, 85 (02) :79-85
[5]   Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis [J].
Takaori, Koji ;
Nakamura, Jin ;
Yamamoto, Shinya ;
Nakata, Hirosuke ;
Sato, Yuki ;
Takase, Masayuki ;
Nameta, Masaaki ;
Yamamoto, Tadashi ;
Economides, Aris N. ;
Kohno, Kenji ;
Haga, Hironori ;
Sharma, Kumar ;
Yanagita, Motoko .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2016, 27 (08) :2393-2406
1