Impact of dairy consumption on essential hypertension: a clinical study

被引:29
作者
Drouin-Chartier, Jean-Philippe [1 ]
Gigleux, Iris [1 ]
Tremblay, Andre J. [1 ]
Poirier, Luc [2 ]
Lamarche, Benoit [1 ]
Couture, Patrick [1 ,2 ]
机构
[1] Univ Laval, Inst Nutr & Funct Foods INAF, Quebec City, PQ G1V 0A6, Canada
[2] Univ Laval, CHUQ Res Ctr, Quebec City, PQ G1V 0A6, Canada
关键词
Dairy products; Nutrition; Clinical trial; Essential hypertension; Ambulatory monitoring; AMBULATORY BLOOD-PRESSURE; PRODUCTS; CALCIUM; DISEASE; METAANALYSIS; PREVENTION; HEALTH;
D O I
10.1186/1475-2891-13-83
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Several studies have presented evidence suggesting that dairy consumption has beneficial effects on blood pressure (BP) in healthy subjects; however, only a few studies have examined this possibility in patients with established essential hypertension using ambulatory blood pressure monitoring. The objective of this study was to investigate how consuming dairy products impacts mean daytime systolic and diastolic BP in men and women with mild to moderate essential hypertension. Methods: Eighty-nine men and women with systolic BP >= 135 mm Hg and <= 160 mm Hg and diastolic BP <= 110 mm Hg were enrolled in this single-blind, randomized, cross-over, controlled study. Participants had to incorporate three daily servings of dairy products or control products equivalent in macronutrients and sodium during four-week treatment phases. Twenty-four hour ambulatory BP and endothelial function were assessed at screening and at the end of each dietary phase. Results: The consumption of three daily servings of dairy products led to a significant reduction in mean daytime ambulatory systolic BP (-2 mm Hg; P = 0.05) in men compared with readings after the control phase. In women, dairy consumption had no effect on ambulatory systolic BP. Moreover, endothelial function was significantly improved by dairy consumption in the whole cohort. Conclusion: These data indicate that the consumption of three daily servings of dairy products have beneficial effects on daytime systolic ambulatory BP compared to a heart-healthy, dairy-free, diet in men with mild to moderate essential hypertension.
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页数:9
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